ArticleHearing research2019
Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats.
Article in Hearing research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Structural and Functional Brain Alterations Induced by Noise Exposure: A Comprehensive Review.NeuroSci · 2026Review
- Is Work-Related Hearing Loss Associated With Dementia? Evidence From a High-Risk Population.American journal of industrial medicine · 2025Article
- NFAT3-FasL axis synchronously regulates apoptosis and necroptosis in murine cochlear outer hair cells after noise trauma.Frontiers in molecular neuroscience · 2024Article
- Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice.Environmental health perspectives · 2023Article
- Noise-induced hippocampal damage: potential mechanisms.Neural regeneration research · 2022Article
- Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function.Frontiers in neuroscience · 2022Article
- Electrophysiology and the magnetic sense: a guide to best practice.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Review
- Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress.Frontiers in integrative neuroscience · 2022Review
- Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model.Frontiers in neuroscience · 2022Article
- Article
- Does hearing loss lead to dementia? A review of the literature.Hearing research · 2021Review
- Environmental noise degrades hippocampus-related learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure.Frontiers in neuroscience · 2021Article
- Occupational Noise: Auditory and Non-Auditory Consequences.International journal of environmental research and public health · 2020Review
- Effect of acute noise trauma on the gene expression profile of the hippocampus.BMC neuroscience · 2020Article
- Blast-induced hearing loss suppresses hippocampal neurogenesis and disrupts long term spatial memory.Hearing research · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Although the effects of intense noise exposure on the peripheral and central auditory pathway have been well characterized, its effects on non-classical auditory structures in the brain, such as the hippocampus, are less well understood. Previously, we demonstrated that noise-induced hearing loss causes a significant long-term reduction in hippocampal neurogenesis and cell proliferation. Given the known suppressive effects of stress hormones on neurogenesis, the goal of the present study was to determine if activation of the stress response is an underlying mechanism for the long-term reduction in hippocampal neurogenesis observed following noise trauma. To accomplish this, we monitored basal and reactive blood plasma levels of the stress hormone corticosterone in rats for ten weeks following acoustic trauma, and quantified changes in hippocampal glucocorticoid and mineralocorticoid receptors. Our results indicate that long-term auditory deprivation does not cause a persistent increase in basal or reactive stress hormone levels in the weeks following noise exposure. Instead, we observed a greater decline in reactive corticosterone release in noise-exposed rats between the first and tenth week of sampling compared to control rats. We also observed a significant increase in hippocampal glucocorticoid receptor expression which may cause greater hippocampal sensitivity to circulating glucocorticoid levels and result in glucocorticoid-induced suppression of neurogenesis, as well as increased feedback inhibition on the HPA axis. No change in mineralocorticoid receptor expression was observed between control and noise exposed rats. These results highlight the adverse effect of intense noise exposure and auditory deprivation on the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.