ReviewCurrent opinion in neurobiology2019
Convolutional nets for reconstructing neural circuits from brain images acquired by serial section electron microscopy.
Review in Current opinion in neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Synaptic Organization of the Primate Retina: Toward a Human Foveal Connectome.Annual review of vision science · 2026Review
- Approaching a connectome of the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- TriSAM: Tri-Plane SAM for Zero-Shot Cortical Blood Vessel Segmentation in VEM Images.IEEE journal of biomedical and health informatics · 2025Article
- Comparative prospects of imaging methods for whole-brain mammalian connectomics.Cell reports methods · 2025Review
- Predicting modular functions and neural coding of behavior from a synaptic wiring diagram.Nature neuroscience · 2024Article
- WASPSYN: A Challenge for Domain Adaptive Synapse Detection in Microwasp Brain Connectomes.IEEE transactions on medical imaging · 2024Article
- Tracing nerve fibers with volume electron microscopy to quantitatively analyze brain connectivity.Communications biology · 2024Article
- Petascale pipeline for precise alignment of images from serial section electron microscopy.Nature communications · 2024Article
- vEMstitch: an algorithm for fully automatic image stitching of volume electron microscopy.GigaScience · 2024Article
- Multi-layered maps of neuropil with segmentation-guided contrastive learning.Nature methods · 2023Article
- CAVE: Connectome Annotation Versioning Engine.bioRxiv : the preprint server for biology · 2023Article
- Neuronal wiring diagram of an adult brain.bioRxiv : the preprint server for biology · 2023Article
- SynapseCLR: Uncovering features of synapses in primary visual cortex through contrastive representation learning.Patterns (New York, N.Y.) · 2023Article
- Article
- Joint reconstruction of neuron and ultrastructure via connectivity consensus in electron microscope volumes.BMC bioinformatics · 2022Article
- How innovations in methodology offer new prospects for volume electron microscopy.Journal of microscopy · 2022Review
- Article
- Automated Synapse Detection Method for Cerebellar Connectomics.Frontiers in neuroanatomy · 2022Article
- RealNeuralNetworks.jl: An Integrated Julia Package for Skeletonization, Morphological Analysis, and Synaptic Connectivity Analysis of Terabyte-Scale 3D Neural Segmentations.Frontiers in neuroinformatics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neural circuits can be reconstructed from brain images acquired by serial section electron microscopy. Image analysis has been performed by manual labor for half a century, and efforts at automation date back almost as far. Convolutional nets were first applied to neuronal boundary detection a dozen years ago, and have now achieved impressive accuracy on clean images. Robust handling of image defects is a major outstanding challenge. Convolutional nets are also being employed for other tasks in neural circuit reconstruction: finding synapses and identifying synaptic partners, extending or pruning neuronal reconstructions, and aligning serial section images to create a 3D image stack. Computational systems are being engineered to handle petavoxel images of cubic millimeter brain volumes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.