Evidence map›Paper›PMID 31071473›Full record

ReviewMagnetic resonance imaging2019

Precision diagnostics based on machine learning-derived imaging signatures.

Christos Davatzikos, Aristeidis Sotiras, Yong Fan, Mohamad Habes, Guray Erus, Saima Rathore, Spyridon Bakas, Rhea Chitalia, Aimilia Gastounioti, Despina Kontos

Abstract readReview
In one paragraph

Review in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
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  16. AI in MRI: A case for grassroots deep learning.Magnetic resonance imaging · 2019
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christos DavatzikosCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America. Electronic address: Christos.davatzikos@uphs.upenn.edu.
Aristeidis SotirasCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Yong FanCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Mohamad HabesCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Guray ErusCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Saima RathoreCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Spyridon BakasCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Rhea ChitaliaCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Aimilia GastouniotiCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.
Despina KontosCenter for Biomedical Image Computing and Analytics, University of Pennsylvania, United States of America.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Statistical atlases of brain tumor MRI:do imaging phenotypes predict progression?R01NS042645 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2002 to 2024
$8.7M
Machine Learning and Large-scale Imaging analytics for dimensional representations of brain trajectories in aging and preclinical Alzheimer's Disease: The brain aging chart and the iSTAGING consortiumRF1AG054409 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2023
$6.3M
Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Effect of Breast Density on Screening Recall with Digital Breast TomosynthesisR01CA161749 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2012 to 2021
$3.6M
Cancer imaging phenomics software suite: application to brain and breast cancerU24CA189523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, KONTOS, DESPINA · 2015 to 2019
$3.2M
Radiogenomic Biomarkers of Breast Cancer RecurrenceR01CA223816 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHODOSH, LEWIS A, KONTOS, DESPINA · 2018 to 2022
$3.1M
Mapping Heterogeneity of Neuroanatomical Imaging Signatures of Psychosis via Pattern AnalysisR01MH112070 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2020
$2.7M
Multi-parametric 4-D Imaging Biomarkers for Neoadjuvant Treatment ResponseR01CA197000 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2016 to 2020
$2.4M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
Learning radiomic signatures to early predict response of rectal cancer patients to neoadjuvant chemoradiation therapyR21CA223358 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG · 2018 to 2019
$380k
NCATS NIH HHS UL1 TR001878NCI NIH HHS R01 CA161749NCI NIH HHS R01 CA197000NCI NIH HHS R01 CA223816NCI NIH HHS R21 CA223358NCI NIH HHS U24 CA189523NIA NIH HHS RF1 AG054409NIBIB NIH HHS R01 EB022573NIH HHS S10 OD023495NIMH NIH HHS R01 MH112070NINDS NIH HHS R01 NS042645
6 · The paper itself

Abstract

The complexity of modern multi-parametric MRI has increasingly challenged conventional interpretations of such images. Machine learning has emerged as a powerful approach to integrating diverse and complex imaging data into signatures of diagnostic and predictive value. It has also allowed us to progress from group comparisons to imaging biomarkers that offer value on an individual basis. We review several directions of research around this topic, emphasizing the use of machine learning in personalized predictions of clinical outcome, in breaking down broad umbrella diagnostic categories into more detailed and precise subtypes, and in non-invasively estimating cancer molecular characteristics. These methods and studies contribute to the field of precision medicine, by introducing more specific diagnostic and predictive biomarkers of clinical outcome, therefore pointing to better matching of treatments to patients.

Indexed as

Machine LearningBiomarkersBrainBrain DiseasesHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingPrecision MedicineBiomarkers

Identifiers

PMID31071473
PMCPMC6832825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.