Evidence map›Paper›PMID 31071294›Full record

ArticleCell host & microbe2019

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.

Eric M Brown, Xiaobo Ke, Daniel Hitchcock, Sarah Jeanfavre, Julian Avila-Pacheco, Toru Nakata, Timothy D Arthur, Nadine Fornelos, Cortney Heim, Eric A Franzosa and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 293 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 4 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

293 citing papers in PubMed, 4 syntheses or guidelines pooled it, 530 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Bacterial-derived cyclic lipopeptides suppress dauer arrest inbioRxiv : the preprint server for biology · 2026
    Article
  13. Review
  14. Infection and immunity · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  20. Review

233 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Eric M BrownBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xiaobo KeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Novartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA.
Daniel HitchcockBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sarah JeanfavreBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Julian Avila-PachecoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Toru NakataBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Timothy D ArthurBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Nadine FornelosBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Cortney HeimNovartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA.
Eric A FranzosaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Nicki WatsonW. M. Keck Microscopy Facility, The Whitehead Institute, Cambridge, MA 02142, USA.
Curtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Henry J HaiserNovartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA.
Glen DillowNovartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA.
Daniel B GrahamBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
B Brett FinlayMichael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Aleksandar D KosticSection on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.
Jeffrey A PorterNovartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA.
Hera VlamakisBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
Broad Institute · USNovartis (United States) · USHarvard University · USMassachusetts Institute of Technology · USJoslin Diabetes Center · USUniversity of British Columbia · CAWhitehead Institute for Biomedical Research · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
A comprehensive platform for novel therapy development from the microbiomeR24DK110499 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS · 2017 to 2021
$7.7M
Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopyR01AT009708 · NCCIH · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, XAVIER, RAMNIK J · 2017 to 2021
$3.3M
NCCIH NIH HHS R01 AT009708NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R24 DK110499
6 · The paper itself

Abstract

Sphingolipids are structural membrane components and important eukaryotic signaling molecules. Sphingolipids regulate inflammation and immunity and were recently identified as the most differentially abundant metabolite in stool from inflammatory bowel disease (IBD) patients. Commensal bacteria from the Bacteroidetes phylum also produce sphingolipids, but the impact of these metabolites on host pathways is largely uncharacterized. To determine whether bacterial sphingolipids modulate intestinal health, we colonized germ-free mice with a sphingolipid-deficient Bacteroides thetaiotaomicron strain. A lack of Bacteroides-derived sphingolipids resulted in intestinal inflammation and altered host ceramide pools in mice. Using lipidomic analysis, we described a sphingolipid biosynthesis pathway and revealed a variety of Bacteroides-derived sphingolipids including ceramide phosphoinositol and deoxy-sphingolipids. Annotating Bacteroides sphingolipids in an IBD metabolomic dataset revealed lower abundances in IBD and negative correlations with inflammation and host sphingolipid production. These data highlight the role of bacterial sphingolipids in maintaining homeostasis and symbiosis in the gut.

Indexed as

Host Microbial InteractionsAnimalsBacteroides thetaiotaomicronGerm-Free LifeHomeostasisInflammatory Bowel DiseasesIntestinesMiceSphingolipidsSymbiosisSphingolipidsBacteroidesinflammationinflammatory bowel diseaseinnate immunitymetabolismmicrobiomesphingolipids

Identifiers

PMID31071294
PMCPMC6544385
OpenAlexW2944330168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.