ArticleJournal of experimental botany2019
Evolutionary comparison of competitive protein-complex formation of MYB, bHLH, and WDR proteins in plants.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 77 citations in OpenAlex.
- Evolutionary and functional divergence of MYB regulatory networks in flavonoid biosynthesis across Poaceae, non-Poaceae monocots, and eudicot horticultural plants.Horticulture research · 2026Review
- Analysis of BpbHLH Gene Family Responsive to MeJA Signalling in Betula platyphylla Suk. and Functional Mechanisms of BpbHLH42/44 in Genetic Improvement and Triterpenoid Biosynthesis.Plant biotechnology journal · 2026Article
- GmMYB4 Positively Regulates Isoflavone Biosynthesis via the GmMAPK6-GmMYB4-MBW Module in Soybean.Plant biotechnology journal · 2026Article
- Metabolome and transcriptome integration provide insights into petal color variation of Chrysanthemum indicum.BMC plant biology · 2026Article
- Genome-wide identification of MYC transcription factors in Chrysanthemum morifolium and CmMYC25 promotes petal anthocyanin accumulation.Plant cell reports · 2026Article
- Responses and adaptations of plants to abiotic stress: transcriptional regulation of secondary metabolic pathways, metabolomics, and nanobiological approaches.Frontiers in genetics · 2026Review
- Three bilberry bHLHs of subgroup IIIf play divergent roles in fruit anthocyanin and flavonoid biosynthesis.Scientific reports · 2025Article
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Regulatory mechanisms of trichome and root hair development in Arabidopsis.Plant molecular biology · 2024Review
- Transcription factors BZR1 and PAP1 cooperate to promote anthocyanin biosynthesis in Arabidopsis shoots.The Plant cell · 2024Article
- Comparative transcriptomic analysis of the nodulation-competent zone and inference of transcription regulatory network in silicon applied Glycine max [L.]-Merr. Roots.Plant cell reports · 2024Article
- Quantitative analysis of MBW complex formation in the context of trichome patterning.Frontiers in plant science · 2024Article
- Evolutionary studies of the bHLH transcription factors belonging to MBW complex: their role in seed development.Annals of botany · 2023Review
- Association Analysis of Transcriptome and Targeted Metabolites Identifies Key Genes Involved inInternational journal of molecular sciences · 2023Article
- A comprehensive overview of cotton genomics, biotechnology and molecular biological studies.Science China. Life sciences · 2023Review
- Identification and Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Genome-Wide Investigation and Functional Analysis Reveal ThatInternational journal of molecular sciences · 2023Article
- A spatiotemporal atlas of organogenesis in the development of orchid flowers.Nucleic acids research · 2022Article
- Comparative Metabolome and Transcriptome Analysis of Anthocyanin Biosynthesis in White and Pink Petals of Cotton (International journal of molecular sciences · 2022Article
- A newly characterized allele of ZmR1 increases anthocyanin content in whole maize plant and the regulation mechanism of different ZmR1 alleles.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
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4 authors at 1 institution in 1 country.
Funding
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Abstract
A protein complex consisting of a MYB, basic Helix-Loop-Helix, and a WDR protein, the MBW complex, regulates five traits, namely the production of anthocyanidin, proanthocyanidin, and seed-coat mucilage, and the development of trichomes and root hairs. For complexes involved in trichome and root hair development it has been shown that the interaction of two MBW proteins can be counteracted by the respective third protein (called competitive complex formation). We examined competitive complex formation for selected MBW proteins from Arabidopsis thaliana, Arabis alpina, Gossypium hirsutum, Petunia hybrida, and Zea mays. Quantitative analyses of the competitive binding of MYBs and WDRs to bHLHs were done by pull-down assays using ProtA- and luciferase-tagged proteins expressed in human HEC cells. We found that some bHLHs show competitive complex formation whilst others do not. Competitive complex formation strongly correlated with a phylogenetic tree constructed with the bHLH proteins under investigation, suggesting a functional relevance. We demonstrate that this different behavior can be explained by changes in one amino acid and that this position is functionally relevant in trichome development but not in anthocyanidin regulation.
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