Evidence map›Paper›PMID 31071124›Full record

Trial reportPloS one2019

Sero-epidemiological study in prediction of the risk groups for measles outbreaks in Vojvodina, Serbia.

Mioljub Ristić, Vesna Milošević, Snežana Medić, Jelena Djekić Malbaša, Smiljana Rajčević, Jasmina Boban, Vladimir Petrović

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mioljub RistićUniversity of Novi Sad, Faculty of Medicine, Department of Epidemiology, Novi Sad, Serbia.ORCID 0000-0002-6923-189X
Vesna MiloševićUniversity of Novi Sad, Faculty of Medicine, Department of Microbiology with Parasitology and Immunology, Novi Sad, Serbia.
Snežana MedićUniversity of Novi Sad, Faculty of Medicine, Department of Epidemiology, Novi Sad, Serbia.
Jelena Djekić MalbašaUniversity of Novi Sad, Faculty of Medicine, Department of Epidemiology, Novi Sad, Serbia.
Smiljana RajčevićUniversity of Novi Sad, Faculty of Medicine, Department of Epidemiology, Novi Sad, Serbia.
Jasmina BobanUniversity of Novi Sad, Faculty of Medicine, Department of Radiology, Novi Sad, Serbia.
Vladimir PetrovićUniversity of Novi Sad, Faculty of Medicine, Department of Epidemiology, Novi Sad, Serbia.
University of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-stratified serologic surveys provide insight into the gaps of measles-specific immunity as well as estimates of the age-specific seroprevalence. The aim of this study was to describe the measles sero-epidemiology in Vojvodina before the occurrence of outbreak in 2017/18 and to discuss preventive measures for potential future epidemics.

methodsA seroprevalence study was conducted from April 2015 to June 2017 on serum bank of 3199 residual samples. Study was performed prior to the last measles outbreak in Vojvodina that occurred between 12th November 2017 and 30th June 2018. Measles-specific IgG antibodies were determined using an indirect chemiluminescent immunoassay (CLIA).

resultsMedian age of enrolled participants was 20 years (IQR 11-37). Overall, 86.9% serum samples were seropositive. The highest proportion of measles seronegativity was observed in children aged 12-23 months of age and in adults aged 20-39 years (56.1% and 18.5%, respectively). Prevalence of measles seronegativity above WHO target levels susceptibility was observed in the following age groups: 2, 7, 13, 15, and among all adults aged between 20 and 49 years. Out of total measles outbreak cases (177), there were 91 (51.4%) participants aged 20-39 years. A significant positive correlation was observed between measles seronegativity and the number of reported measles cases aged ≥ 12 months (r = 0.4675, p = 0.0213).

conclusionsIn order to prevent new outbreaks and achieve the elimination of measles in Vojvodina, the vaccination coverage of both measles-mumps-rubella (MMR1 and MMR2) vaccines needs to be improved and sustained. Educational campaigns for the improvement of acceptance and timely vaccination with vaccine against measles among doctors and the general population are crucial. Our results indicate possible gap in measles protection in adults born during implementation of one dose of measles vaccine and prioritize supplementary immunization activities targeting adults in Vojvodina, Serbia.

Indexed as

Disease OutbreaksImmunizationMeaslesAdolescentAdultAntibodies, ViralChildChild, PreschoolFemaleHumansImmunoglobulin GInfantMaleMeasles-Mumps-Rubella VaccineMiddle AgedRisk FactorsAntibodies, ViralImmunoglobulin GMeasles-Mumps-Rubella Vaccine

Identifiers

PMID31071124
PMCPMC6508608
OpenAlexW2944519062

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.