ArticlePloS one2019
Epidemiology and clinical profile of individuals with cleft lip and palate utilising specialised academic treatment centres in South Africa.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Genetic markers for non-syndromic orofacial clefts in populations of European ancestry: a meta-analysis.Scientific reports · 2022Pooled it
- Epidemiological and Clinical Profile of Cleft Lip and/or Palate in Mbujimayi: A Cross-Sectional Study.Health science reports · 2026Article
- Comparison of Goslon Yardstick and Cephalometric Analysis in Nonsyndromic Unilateral Cleft lip and Palate Individuals in the Western Cape, South Africa.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Barriers and delays in access to cleft surgery among children with cleft deformities in Rwanda: a qualitative study.BMJ open · 2026Article
- Unveiling Epidemiologic Insights: A Case-Control Study of Congenital Cleft Lip and/or Palate Using Association Rule Mining.BioMed research international · 2026Observational
- Quality of life of children treated for cleft lip or palate in a selected South African population: a questionnaire-based survey of guardian/parent perspectives.Oral and maxillofacial surgery · 2025Article
- Mortality Associated with Orofacial Clefts in Brazil.Dentistry journal · 2025Article
- An epidemiological investigation of oral and maxillofacial anomalies in newborns and their relation to parental health in the Ha'il Region, Saudi Arabia.Scientific reports · 2025Article
- Article
- Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review.Children (Basel, Switzerland) · 2024Article
- The Global Occurrences of Cleft Lip and Palate in Pediatric Patients and Their Association with Demographic Factors: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study.Archives of craniofacial surgery · 2024Article
- What is the optimal assessment of speech? A multicentre, international evaluation of speech assessment in 2500 patients with a cleft.BMJ open · 2023Article
- Nasal Cartilage Molding in a Case of Unilateral Cleft Lip and Alveolus (Type D): A Case Report.Cureus · 2023Article
- Isolated nonsyndromic cleft palate: multicenter epidemiological study in the Brazil.BMC oral health · 2023Article
- The burden, prevention and care of infants and children with congenital anomalies in sub-Saharan Africa: A scoping review.PLOS global public health · 2023Article
- Recent Advances in Nasoalveolar Molding Therapy Using 3D Technology.Craniomaxillofacial trauma & reconstruction · 2022Review
- Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review.Children (Basel, Switzerland) · 2022Review
- Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022Article
- The characteristics and perioperative outcomes of children with orofacial clefts managed at an academic hospital in Johannesburg, South Africa.BMC pediatrics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study was conducted to determine the epidemiology and clinical profile of individuals with cleft lip and/or palate (CLP) utilizing specialized academic treatment centres in South Africa's public health sector. MATERIALS AND
methodsThe Human Research Ethics Committee of the University of the Witwatersrand in Johannesburg provided ethical approval for the study. We conducted a retrospective record review of all cases of CLP treated at the specialised academic centres for the two-year period from 1 January 2013 until 31 December 2014. We used a structured, pre-tested record review form to obtain demographic, clinical and treatment information on each CLP case. We used Stata 13 to analyse the data and conducted statistical tests at 5% significance level.
resultsWe analysed 699 records of individuals with CLP. The estimated prevalence of CLP in the South African public health sector was 0.3 per 1000 live births, with provincial variation of 0.1/1000 to 1.2/1000. The distribution of clefts was: 35.3% cleft palate; 34.6% cleft lip and palate; 19.0% cleft lip and other cleft anomalies at 2%. Of the total number of CLP, 47.5% were male and 52.5% female, and this difference was statistically significant (p<0.001). The majority of clefts occurred on the left for males (35.5%) and palate for females (43.4%), with a male predominance of unilateral cleft lip and palate (53.3%).
conclusionThe study findings should inform the implementation of South Africa's planned birth defect surveillance system and health service planning for individuals with CLP.
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