ArticlePLoS biology2019
Fat body-specific vitellogenin expression regulates host-seeking behaviour in the mosquito Aedes albopictus.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- The evolution of reproduction without blood feeding in an invasive vector mosquito Aedes albopictus.BMC biology · 2026Article
- Two neuropeptides that promote blood feeding ineLife · 2026Article
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- Behavioral heterogeneity in host seeking and post-feeding suppression among disease vector mosquitoes.Communications biology · 2026Article
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Article
- Behavioral heterogeneity in host-seeking and post-feeding suppression among disease vector mosquitoes.bioRxiv : the preprint server for biology · 2025Article
- Roles of Vitellogenin and Its Receptor Genes in Female Reproduction of the Cigarette Beetle,Insects · 2025Article
- Phosphoproteomics analyses ofHeliyon · 2024Article
- Reciprocal interactions between neuropeptide F and RYamide regulate host attraction in the mosquitoProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Phenotypic variation in biting behavior associated with differences in expression of olfactory genes in the vector mosquito, Aedes albopictus (Diptera: Culicidae).Journal of medical entomology · 2024Article
- Article
- Interaction between the flagellum ofFrontiers in microbiology · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Ad libitum consumption of protein- or peptide-sucrose solutions stimulates egg formation by prolonging the vitellogenic phase of oogenesis in anautogenous mosquitoes.Parasites & vectors · 2022Article
- Influence of Host Blood Meal Source on Gut Microbiota of Wild CaughtMicroorganisms · 2022Article
- Deltamethrin interacts with Culex quinquefasciatus odorant-binding protein: a novel potential resistance mechanism.Parasites & vectors · 2022Article
- Structure prediction of honey bee vitellogenin: a multi-domain protein important for insect immunity.FEBS open bio · 2022Article
- Uncovering the Worldwide Diversity and Evolution of the Virome of the MosquitoesMicroorganisms · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high vector competence of mosquitoes is intrinsically linked to their reproductive strategy because females need a vertebrate blood meal to develop large batches of eggs. However, the molecular mechanisms and pathways regulating mosquito host-seeking behaviour are largely unknown. Here, we test whether host-seeking behaviour may be linked to the female's energy reserves, with low energy levels triggering the search for a nutrient-rich blood meal. Our results demonstrate that sugar feeding delays host-seeking behaviour in the invasive tiger mosquito Aedes albopictus, but the levels of energy reserves do not correlate with changes in host-seeking behaviour. Using tissue-specific gene expression analyses, we show for the first time, to our knowledge, that sugar feeding alone induces a transient up-regulation of several vitellogenesis-related genes in the female fat body, resembling the transcriptional response after a blood meal. Specifically, high expression levels of a vitellogenin gene (Vg-2) correlated with the lowest host-seeking activity of sugar-fed females. Knocking down the Vg-2 gene via RNA interference (RNAi) restored host-seeking behaviour in these females, firmly establishing that Vg-2 gene expression has a pivotal role in regulating host-seeking behaviour in young Ae. albopictus females. The identification of a molecular mechanism regulating host-seeking behaviour in mosquitoes could pave the way for novel vector control strategies aiming to reduce the biting activity of mosquitoes. From an evolutionary perspective, this is the first demonstration of vitellogenin genes controlling feeding-related behaviours in nonsocial insects, while vitellogenins are known to regulate caste-specific foraging and brood-care behaviours in eusocial insects. Hence, this work confirms the key role of vitellogenin in controlling feeding-related behaviours in distantly related insect orders, suggesting that this function could be more ubiquitous than previously thought.
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