ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019
Water deprivation does not augment sympathetic or pressor responses to sciatic afferent nerve stimulation in rats or to static exercise in humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03560869 (Sympathetic Reactivity to Water Restriction in Young and Older Adults), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sympathetic Reactivity to Water Restriction in Young and Older Adults
Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Acute kidney injury biomarker responses in young and older female adults following mild hypohydration.American journal of physiology. Renal physiology · 2026Trial
- Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans.Prehospital emergency care · 2023Trial
- Low-dose morphine reduces pain perception and blood pressure, but not muscle sympathetic outflow, responses during the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Low-dose fentanyl reduces pain perception, muscle sympathetic nerve activity responses, and blood pressure responses during the cold pressor test.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Short-term water deprivation attenuates the exercise pressor reflex in older female adults.Physiological reports · 2020Trial
- Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Sex differences in central salt sensing in the human brain.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Differential effects of female aging on sympathetic blood pressure regulation at rest and during stress in humans.Physiological reports · 2025Article
- The effects of body hydration on perceptual responses during blood flow restriction exercise.Physiological reports · 2025Article
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology · 2024Article
- Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Acute nasal breathing lowers diastolic blood pressure and increases parasympathetic contributions to heart rate variability in young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Adjusting for muscle strength and body size attenuates sex differences in the exercise pressor reflex in young adults.American journal of physiology. Heart and circulatory physiology · 2023Article
- Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults.The American journal of clinical nutrition · 2023Article
- Hydration Status and Cardiovascular Function.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Excess dietary salt intake excites central sympathetic networks, which may be related to plasma hypernatremia. Plasma hypernatremia also occurs following water deprivation (WD). The purpose of this study was to test the hypothesis that WD induces hypernatremia and consequently augments sympathetic and pressor responses to sympathoexcitatory stimuli in rats and humans. Sympathetic nerve activity (SNA) and arterial blood pressure (ABP) responses to sciatic afferent nerve stimulation (2-20 Hz) and chemical stimulation of the rostral ventrolateral medulla (RVLM) were assessed in rats after 48 h of WD and compared with normally hydrated control rats (CON). In a parallel randomized-crossover human experiment (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.