Evidence map›Paper›PMID 31070932›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species.

Stephanie J King, Michael Bunz, Alfred Chappell, Michael Scharl, Michael Docherty, Barbara Jung, Christian Lytle, Declan F McCole

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. IntestinalJournal of geriatric cardiology : JGC · 2023
    Article
  3. Review
  4. Metformin Inhibits NaFrontiers in physiology · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Stephanie J KingDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Michael BunzDivision of Gastroenterology, School of Medicine, University of California, San Diego, La Jolla, California.
Alfred ChappellDivision of Gastroenterology, School of Medicine, University of California, San Diego, La Jolla, California.
Michael ScharlDivision of Gastroenterology, School of Medicine, University of California, San Diego, La Jolla, California.
Michael DochertyDivision of Gastroenterology, School of Medicine, University of California, San Diego, La Jolla, California.
Barbara JungDivision of Gastroenterology, School of Medicine, University of California, San Diego, La Jolla, California.
Christian LytleDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Declan F McColeDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
University of California, San Diego · USUniversity of California, Riverside · USSwiss Integrative Center for Human Health · CH

Funding

A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
NIDDK NIH HHS R01 DK091281
6 · The paper itself

Abstract

Reactive oxygen species such as H

Indexed as

Inflammatory Bowel DiseasesAMP-Activated Protein KinasesCarrier ProteinsCells, CulturedHumansHydrogen PeroxideIntestinal MucosaIon TransportPhosphatidylinositol 3-KinasesReactive Oxygen SpeciesSignal TransductionSolute Carrier Family 12, Member 2AMP-Activated Protein KinasesCarrier ProteinsHydrogen PeroxidePhosphatidylinositol 3-KinasesReactive Oxygen SpeciesSolute Carrier Family 12, Member 2carbacholchlorideepithelialHT-29hydrogen peroxideT84

Identifiers

PMID31070932
PMCPMC6734373
OpenAlexW2943994064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.