ArticleJournal of anatomy2019
Callosal septa express guidance cues and are paramedian guideposts for human corpus callosum development.
Article in Journal of anatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
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- Fetal indusium griseum is a possible biomarker of the regularity of brain midline development in 3T MR imaging: A retrospective observational study.Acta obstetricia et gynecologica Scandinavica · 2024Observational
- Characterizing microstructural development in the fetal brain using diffusion MRI from 23 to 36 weeks of gestation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Fetal MRI based brain atlas analysis detects initial in utero effects of prenatal alcohol exposure.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis.International journal of molecular sciences · 2022Article
- Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.Nature communications · 2022Article
- Complex Neurochemical Microstructure of the Stria Terminalis in Infant and Adult Macaque Monkey.Frontiers in neuroanatomy · 2022Article
- The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries.Frontiers in cell and developmental biology · 2022Article
- Development of human white matter pathways in utero over the second and third trimester.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
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Abstract
The early development and growth of the corpus callosum are supported by several midline transient structures in mammals that include callosal septa (CS), which are present only in the second half of gestation in humans. Here we provide new data that support the guidance role of CS in corpus callosum development, derived from the analysis of 46 postmortem fetal brains, ranging in age from 16 to 40 post conception weeks (PCW). Using immunohistochemical methods, we show the expression pattern of guidance cues ephrinA4 and neogenin, extracellular protein fibronectin, as well as non-activated microglia in the CS. We found that the dynamic changes in expression of guidance cues, cellular and extracellular matrix constituents in the CS correlate well with the growth course of the corpus callosum at midsagittal level. The CS reach and maintain their developmental maximum between 20 and 26 PCW and can be visualized as hypointense structures in the ventral callosal portion with ex vivo (in vitro) T2-weighted 3T magnetic resonance imaging (MRI). The maximum of septal development overlaps with an increase in the callosal midsagittal area, whereas the slow, gradual resolution of CS coincides with a plateau of midsagittal callosal growth. The recognition of CS existence in human fetal brain and the ability to visualize them by ex vivoMRI attributes a potential diagnostic value to these transient structures, as advancement in imaging technologies will likely also enable in vivoMRI visualization of the CS in the near future.
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