Evidence map›Paper›PMID 31070769›Full record

ArticleSleep2019

Trait-like vulnerability of higher-order cognition and ability to maintain wakefulness during combined sleep restriction and circadian misalignment.

Kate E Sprecher, Hannah K Ritchie, Tina M Burke, Christopher M Depner, Alexandra N Smits, Pieter C Dorrestein, Monika Fleshner, Rob Knight, Christopher A Lowry, Fred W Turek and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kate E SprecherSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.
Hannah K RitchieSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.
Tina M BurkeSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.
Christopher M DepnerSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.
Alexandra N SmitsSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Microbiome Innovation and Collaborative Mass Spectrometry Innovation Center, University of California, San Diego, CA.
Monika FleshnerStress Physiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.
Rob KnightDepartments of Pediatrics, Bioengineering and Computer Science and Engineering and Center for Microbiome Innovation, University of California, San Diego, CA.
Christopher A LowryCenter for Neuroscience, University of Colorado-Boulder, Boulder, CO.
Fred W TurekCenter for Sleep and Circadian Biology, Northwestern University, Evanston, IL.
Martha H VitaternaCenter for Sleep and Circadian Biology, Northwestern University, Evanston, IL.
Kenneth P WrightSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado-Boulder, Boulder, CO.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
NCATS NIH HHS UL1 TR002535NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

STUDY

objectivesDetermine stability of individual differences in executive function, cognitive processing speed, selective visual attention, and maintenance of wakefulness during simulated sustained operations with combined sleep restriction and circadian misalignment.

methodsTwenty healthy adults (eight female), aged 25.7 (±4.2 SD), body mass index (BMI) 22.3 (±2.1) kg/m2 completed an 18-day protocol twice. Participants maintained habitual self-selected 8-hour sleep schedules for 2 weeks at home prior to a 4-day laboratory visit that included one sleep opportunity per day: 8 hours on night 1, 3 hours on night 2, and 3 hours on mornings 3 and 4. After 3 days of unscheduled sleep at home, participants repeated the entire protocol. Stability and task dependency of individual differences in performance were quantified by intra-class correlation coefficients (ICC) and Kendall's Tau, respectively.

resultsPerformance on Stroop, Visual Search, and the Maintenance of Wakefulness Test were highly consistent within individuals during combined sleep restriction and circadian misalignment. Individual differences were trait-like as indicated by ICCs (0.54-0.96) classified according to standard criteria as moderate to almost perfect. Individual differences on other performance tasks commonly reported in sleep studies showed fair to almost perfect ICCs (0.22-0.94). Kendall's rank correlations showed that individual vulnerability to sleep restriction and circadian misalignment varied by task and by metric within a task.

conclusionsConsistent vulnerability of higher-order cognition and maintenance of wakefulness to combined sleep restriction and circadian misalignment has implications for the development of precision countermeasure strategies for workers performing safety-critical tasks, e.g. military, police, health care workers and emergency responders.

Indexed as

AdultAttentionCircadian RhythmCognitionExecutive FunctionFemaleHumansIndividualityMalePolysomnographyPsychomotor PerformanceSleepSleep DeprivationSleep Disorders, Circadian RhythmTask Performance and AnalysisWakefulnesscircadian misalignmentindividual differencesMaintenance of Wakefulness Testperformancesex differencessleep restriction

Identifiers

PMID31070769
PMCPMC6941712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.