Evidence map›Paper›PMID 31070471›Full record

Trial reportArteriosclerosis, thrombosis, and vascular biology2019

Group IIA Secretory Phospholipase A

Akintunde O Akinkuolie, Patrick R Lawler, Audrey Y Chu, Michael Caulfield, Jianying Mu, Bo Ding, Fredrik Nyberg, Robert J Glynn, Paul M Ridker, Eva Hurt-Camejo and 2 more

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Arteriosclerosis, thrombosis, and vascular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Trial
  3. The Phospholipase AJournal of lipid and atherosclerosis · 2026
    Review
  4. Association ofBiomedical reports · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. The Link between Prostanoids and Cardiovascular Diseases.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Akintunde O AkinkuolieFrom the Center for Lipid Metabolomics, Division of Preventive Medicine (A.O.A., P.R.L., R.J.G., P.M.R., D.I.C., S.M.), Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Patrick R LawlerFrom the Center for Lipid Metabolomics, Division of Preventive Medicine (A.O.A., P.R.L., R.J.G., P.M.R., D.I.C., S.M.), Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Audrey Y ChuMerck Research Laboratories, Boston, MA (A.Y.C.).
Michael CaulfieldDepartment of Endocrinology & CVD, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA (M.C., J.M.).
Jianying MuDepartment of Endocrinology & CVD, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA (M.C., J.M.).
Bo DingMedical Evidence & Observational Research, Global Medical Affairs (B.D., F.N.), AstraZeneca R&D, Mölndal, Sweden.
Fredrik NybergMedical Evidence & Observational Research, Global Medical Affairs (B.D., F.N.), AstraZeneca R&D, Mölndal, Sweden.
Robert J GlynnFrom the Center for Lipid Metabolomics, Division of Preventive Medicine (A.O.A., P.R.L., R.J.G., P.M.R., D.I.C., S.M.), Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Paul M RidkerFrom the Center for Lipid Metabolomics, Division of Preventive Medicine (A.O.A., P.R.L., R.J.G., P.M.R., D.I.C., S.M.), Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Eva Hurt-CamejoCardiovascular & Metabolic Diseases, Innovative Medicines (E.H.-C.), AstraZeneca R&D, Mölndal, Sweden.
Daniel I ChasmanFrom the Center for Lipid Metabolomics, Division of Preventive Medicine (A.O.A., P.R.L., R.J.G., P.M.R., D.I.C., S.M.), Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Samia MoraFrom the Center for Lipid Metabolomics, Division of Preventive Medicine (A.O.A., P.R.L., R.J.G., P.M.R., D.I.C., S.M.), Department of Medicine, Brigham and Women's Hospital, Boston, MA.
AstraZeneca (Sweden) · SEBrigham and Women's Hospital · USHarvard University · USMassachusetts General Hospital · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USToronto General Hospital · CA

Funding

PRE-DETERMINE: Biologic Markers and MRI SCD Cohort StudyR01HL091069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALBERT, CHRISTINE M · 2008 to 2020
$12.9M
Training Program in the Epidemiology of CVDT32HL007575 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURING, JULIE E., RIDKER, PAUL M. · 1985 to 2019
$5.0M
Total plasma and IgG glycomes, statin therapy and ASCVD eventsR01HL117861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORA, SAMIA · 2013 to 2022
$3.8M
Reducing Inflammation for the Prevention of CVD: A Focus on Eicosanoid PathwaysR01HL134811 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORA, SAMIA · 2017 to 2020
$3.0M
Patient Centered Approaches to Preventing ASCVD EventsK24HL136852 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAMIA MORA · 2018 to 2026
$1.1M
British Heart Foundation FS/12/82/29736Medical Research Council G9521010Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MR/M009203/1NHLBI NIH HHS K24 HL136852NHLBI NIH HHS R01 HL091069NHLBI NIH HHS R01 HL117861NHLBI NIH HHS R01 HL134811NHLBI NIH HHS T32 HL007575
6 · The paper itself

Abstract

Objective- Inflammation is a causal risk factor for cardiovascular disease (CVD). sPLA

Indexed as

AgedAnti-Inflammatory AgentsCardiovascular DiseasesDouble-Blind MethodDyslipidemiasFemaleGenetic Predisposition to DiseaseGroup II Phospholipases A2HumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceInflammationMaleMiddle AgedPolymorphism, Single NucleotidePrimary PreventionAnti-Inflammatory AgentsGroup II Phospholipases A2Hydroxymethylglutaryl-CoA Reductase InhibitorsPLA2G2A protein, humanRosuvastatin Calciumcardiovascular diseaseinflammationprimary preventionrisk factorsecondary prevention

Identifiers

PMID31070471
PMCPMC6534275
OpenAlexW2955231153

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.