ArticleACS sensors2019
Plasmonic Paper Microneedle Patch for On-Patch Detection of Molecules in Dermal Interstitial Fluid.
Article in ACS sensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 78 citations in OpenAlex.
- Reversal Nanoimprinted 3D Plasmonic Sensor Around Microposts for Cell and DNA Detection.Biosensors · 2026Article
- SERS-Based Nano- and Microsystems Toward Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential.Advanced healthcare materials · 2026Review
- Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection.Biosensors · 2025Review
- Curvature-Insensitive Transparent Surface-Enhanced Raman Scattering Substrate Based on Large-Area Ag Nanoparticle-Coated Wrinkled Polystyrene/Polydimethylsiloxane Film for Reliable In Situ Detection.Molecules (Basel, Switzerland) · 2024Article
- Comparison of three methods for collecting interstitial fluid from subcutaneous tissue in mini pigs.MethodsX · 2024Article
- Microneedle Sensors for Point-of-Care Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Review
- Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.Advanced healthcare materials · 2023Article
- Surface potential modulation as a tool for mitigating challenges in SERS-based microneedle sensors.Scientific reports · 2022Article
- Recent advances in porous microneedles: materials, fabrication, and transdermal applications.Drug delivery and translational research · 2022Review
- Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases.Biosensors · 2021Review
- Enhanced extraction of skin interstitial fluid using a 3D printed device enabling tilted microneedle penetration.Scientific reports · 2021Article
- Microneedle arrays for the treatment of chronic wounds.Expert opinion on drug delivery · 2020Review
- Sampling interstitial fluid from human skin using a microneedle patch.Science translational medicine · 2020Article
- Microneedle-based bioassays.Nanoscale advances · 2020Review
- Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.Advanced healthcare materials · 2020Article
- Engineering Microneedles for Therapy and Diagnosis: A Survey.Micromachines · 2020Review
- Refreshable Nanobiosensor Based on Organosilica Encapsulation of Biorecognition Elements.ACS applied materials & interfaces · 2020Article
- Smart Microneedles for Therapy and Diagnosis.Research (Washington, D.C.) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Minimally invasive devices to detect molecules in dermal interstitial fluid (ISF) are desirable for point-of-care diagnostic and monitoring applications. In this study, we developed a microneedle (MN) patch that collects ISF for on-patch biomarker analysis by surface-enhanced Raman scattering (SERS). The micrometer-scale MNs create micropores in the skin surface, through which microliter quantities of ISF are collected onto plasmonic paper on the patch backing. The plasmonic paper was prepared by immobilizing poly(styrenesulfonate) (PSS) coated gold nanorods (AuNRs) on a thin strip of filter paper using plasmonic calligraphy. Negatively charged PSS was used to bind positively charged rhodamine 6G (R6G), which served as a model compound, and thereby localize R6G on AuNR surface. R6G bound on the AuNR surface was detected and quantified by acquiring SERS spectra from the plasmonic paper MN patch. This approach was used to measure pharmacokinetic profiles of R6G in ISF and serum from rats in vivo. This proof-of-concept study indicates that a plasmonic paper MN patch has the potential to enable on-patch measurement of molecules in ISF for research and future medical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.