ArticleCancer medicine2019
The application value of modified thyroid imaging report and data system in diagnosing medullary thyroid carcinoma.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Diagnostic efficiency among Eu-/C-/ACR-TIRADS and S-Detect for thyroid nodules: a systematic review and network meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Accuracy of thyroid imaging reporting and data system category 4 or 5 for diagnosing malignancy: a systematic review and meta-analysis.European radiology · 2020Pooled it
- Review
- Ultrasonographic differentiation of medullary thyroid carcinoma from papillary thyroid carcinoma: quantitative comparison of morphologic features and different TIRADS risk categorizations.BMC medical imaging · 2025Article
- Ultrasonic radiomics in predicting pathologic type for thyroid cancer: a preliminary study using radiomics features for predicting medullary thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Epidemiology, Clinical Presentation, and Diagnosis of Medullary Thyroid Carcinoma.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Comparison of the diagnostic performance and clinical role of different ultrasound-based thyroid malignancy risk stratification systems for medullary thyroid carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- CT and MR imaging features of soft tissue rhabdoid tumor: compared with rhabdomyosarcoma in children.Frontiers in pediatrics · 2023Article
- Diagnostic efficiency of existing guidelines and the AI-SONIC™ artificial intelligence for ultrasound-based risk assessment of thyroid nodules.Frontiers in endocrinology · 2023Article
- Ultrasound features of medullary thyroid cancer as predictors of biological behavior.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- EU-TIRADS-Based Omission of Fine-Needle Aspiration and Cytology from Thyroid Nodules Overlooks a Substantial Number of Follicular Thyroid Cancers.International journal of endocrinology · 2021Article
- Thyroid cancer diagnosis in the era of precision imaging.Journal of thoracic disease · 2020Review
- The application value of modified thyroid imaging report and data system in diagnosing medullary thyroid carcinoma.Cancer medicine · 2019Article
- SPORADIC MEDULLARY THYROID CARCINOMA IN GRAVES' DISEASE.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medullary thyroid carcinoma (MTC) is highly malignant and quite different from the most common papillary thyroid carcinoma (PTC). However, most of the ultrasonic evaluation systems mainly aim at PTC at present. This study aims to evaluate the applicability of modified TI-RADS in diagnosing MTC and compare the sonographic differences of MTC, PTC, and benign nodules. Three thousand two hundred and forty-two thyroid nodules images confirmed by pathology were categorized according to modified TI-RADS and ACR TI-RADS classification. The performances of two TI-RADS were assessed by ROC curves. The correlations between classifications with the pathology and the consistency of different doctors were evaluated. The ultrasonic differences of MTC, PTC, and benign nodules were analyzed. As a result, the number of high suspicious US features increased, the malignant risk of nodules also increased of two classifications, with significant differences between categories (P < 0.001). Spearman correlation coefficients were 0.751 (modified TI-TADS) and 0.744 (ACR TI-RADS). Areas under the ROC curve of the modified TI-RADS and ACR TI-RADS were 0.960 and 0.872 (P < 0.001). At Best cut off points, the diagnostic value of modified TI-RADS was higher than that of ACR TI-RADS with a higher specificity, PPV, accuracy, and Youden index). By using modified TI-RADS to diagnose MTC and PTC, the sensitivity, specificity, NPV, accuracy, and Youden index were higher in MTC than PTC. The Kendall's correlation coefficients were 0.962, 0.930, and 0.987. MTC had special ultrasonography characters compared with PTC and benign nodules. These results suggest that modified TI-RADS is better than ACR TI-RADS in diagnosing thyroid carcinomas. Diagnostic value to MTC of modified TI-RADS is slightly higher than that to PTC, and the categorical results of different doctors were consistent. MTC had several particular features contrast to PTC and benign nodules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.