Evidence map›Paper›PMID 31070092›Full record

ArticleEpigenetics2019

Epigenome modulated xenobiotic detoxification pathways control DMBA-induced breast cancer in agouti A

Simbarashe Mazambani, Madeleine Morris, Venugopalan Cheriyath

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Simbarashe Mazambania Department of Biological and Environmental Sciences , Texas A&M University-Commerce , Commerce , TX , USA.
Madeleine Morrisa Department of Biological and Environmental Sciences , Texas A&M University-Commerce , Commerce , TX , USA.
Venugopalan Cheriyatha Department of Biological and Environmental Sciences , Texas A&M University-Commerce , Commerce , TX , USA.ORCID 0000-0002-6424-2813
East Texas A&M University · US

Funding

Myelodysplastic Syndrome Target Identification and ValidationR03CA198630 · NCI · EAST TEXAS A&M UNIVERSITY · PI CHERIYATH, VENUGOPALAN · 2015 to 2016
$148k
Target Identification and Validation to Overcome Antiestrogen Resistance in ER+ Breast CancerR03CA202427 · NCI · EAST TEXAS A&M UNIVERSITY · PI CHERIYATH, VENUGOPALAN · 2016 to 2017
$141k
NCI NIH HHS R03 CA198630NCI NIH HHS R03 CA202427
6 · The paper itself

Abstract

Environmental xenobiotics with genotoxic activity are carcinogenic. However, individual differences in the susceptibility to xenobiotic-induced breast cancer remain unclear. Since epigenetic modifications could control the expression of metabolic enzymes, our goal was to determine whether epigenome modulated metabolic networks determine susceptibility to xenobiotic-induced breast cancer. The effect of epigenetic background on predisposition to carcinogen 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer development and progression was assessed using the A

Indexed as

AnimalsAnthracenesBreast NeoplasmsDisease Models, AnimalDNA DamageEpigenomeFemaleGene Expression Regulation, NeoplasticHumansLiverMetabolic Detoxication, Phase IMicePiperidinesSignal TransductionXenobiotics3-(2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one on 7,12-dimethylbenz(a)anthraceneAnthracenesPiperidinesXenobiotics12-dimethylbenz[a]anthracene (DMBA)7A/a micebreast cancermetabolism genesphase 2 enzymespseudoagouti miceXenobiotic detoxification

Identifiers

PMID31070092
PMCPMC6557611
OpenAlexW2944421928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.