Evidence map›Paper›PMID 31070085›Full record

ArticleJournal of child neurology2019

Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study.

Gwendolyn J Gerner, Eric I Newman, V Joanna Burton, Brenton Roman, Elizabeth A Cristofalo, Mary Leppert, Michael V Johnston, Frances J Northington, Thierry A G M Huisman, Andrea Poretti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Gwendolyn J Gerner1 Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA.
Eric I Newman4 Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
V Joanna Burton2 Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brenton Roman1 Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA.
Elizabeth A Cristofalo2 Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mary Leppert2 Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael V Johnston1 Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA.
Frances J Northington2 Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thierry A G M Huisman2 Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrea Poretti2 Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USKennedy Krieger Institute · USJohns Hopkins University · USCalvert Memorial Hospital · US

Funding

Adult Biomarkers in Neonatal Brain Injury and DevelopmentR01HD086058 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2016 to 2020
$3.1M
NICHD NIH HHS R01 HD086058
6 · The paper itself

Abstract

aimHypoxic-ischemic encephalopathy is associated with damage to deep gray matter; however, white matter involvement has become recognized. This study explored differences between patients and clinical controls on diffusion tensor imaging, and relationships between diffusion tensor imaging and neurodevelopmental outcomes.

methodDiffusion tensor imaging was obtained for 31 neonates after hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and 10 clinical controls. A subgroup of patients with hypoxic-ischemic encephalopathy (n = 14) had neurodevelopmental outcomes correlated with diffusion tensor imaging scalars.

resultsGroup differences in diffusion tensor imaging scalars were observed in the putamen, anterior and posterior centrum semiovale, and the splenium of the corpus callosum. Differences in these regions of interest were correlated with neurodevelopmental outcomes between ages 20 and 32 months.

conclusionTherapeutic hypothermia may not be a complete intervention for hypoxic-ischemic encephalopathy, as neonatal white matter changes may continue to be evident, but further research is warranted. Patterns of white matter change on neonatal diffusion tensor imaging correlated with neurodevelopmental outcomes in this exploratory pilot study.

Indexed as

Diffusion Tensor ImagingHypothermia, InducedAsphyxia NeonatorumFemaleHumansHypoxia-Ischemia, BrainInfant, NewbornLearningMaleMotor SkillsPilot ProjectsProspective StudiesTreatment OutcomeWhite Matterdiffusion tensor imaginghypoxic-ischemic encephalopathyinfantneurodevelopmentoutcome

Identifiers

PMID31070085
PMCPMC7318916
OpenAlexW2944711506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.