ArticlePsychogeriatrics : the official journal of the Japanese Psychogeriatric Society2020
Moderating effect of cognitive reserve on the association between grey matter atrophy and memory varies with age in older adults.
Article in Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Attentional Function in Patients With Amyotrophic Lateral Sclerosis is Moderated by Age and Education.Brain and behavior · 2026Article
- Education, Cognitive Reserve, and Brain Pathology in Aging and Alzheimer's Disease: Evidence from Preclinical and Symptomatic Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Moderating effect of the domains of the cognitive reserve index questionnaire (CRIq) on longitudinal change slopes in episodic memory across the cognitive aging continuum.Scientific reports · 2026Article
- More cognitive gains from social activity in the oldest-old: evidence from a 10-year longitudinal study.Frontiers in psychology · 2024Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Unraveling the Protective Effects of Cognitive Reserve on Cognition and Brain: A Cross-Sectional Study.International journal of environmental research and public health · 2022Observational
- Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease.Metabolites · 2022Article
- The Paradoxical Effect of Living Alone on Cognitive Reserve and Mild Cognitive Impairment among Women Aged 60+ in Mexico City.International journal of environmental research and public health · 2021Article
- Cognitive Reserve, Executive Function, and Memory in Parkinson's Disease.Brain sciences · 2021Article
- Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults.Alzheimer's research & therapy · 2021Article
- Positive Effects of Education on Cognitive Functioning Depend on Clinical Status and Neuropathological Severity.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 4 countries.
Funding
Abstract
backgroundEducational attainment and verbal intelligence, which indirectly reflect an individual's cognitive reserve (CR), is suggested to buffer the effect of late-life brain degradation on cognitive performance outcome. We aimed to explore how the relationship between whole grey matter volume (GMV) and episodic memory function is altered by CR proxy as well as age in healthy older adults.
methodsElderly Verbal Learning Test (EVLT) and structural magnetic resonance imaging were administered to 110 community-residing older adults. Moderated moderation model tested whether the association between whole GMV and episodic memory was moderated by both CR and chronological age.
resultsThe results showed that the moderating effect of CR on Immediate Recall, Short-delay Recall, and Recognition scores of EVLT differed across age groups. The elderly with higher CR showed steeper GMV effect on EVLT at the Age-Younger condition, while such moderating effect was reversed in the Age-Older condition, suggesting an alleviated brain atrophy effect in higher CR elderly.
conclusionThese findings suggest that although higher CR elderly may exhibit earlier GMV-related memory decline, the buffering effect of CR on the cognitive decline due to brain atrophy would become more evident in old-old elderly people who are likely to have accumulated more neuropathological changes. This study underscores chronological age as an important moderating factor in examining the moderating role of CR in late-life memory function.
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