ReviewCurrent environmental health reports2019
Complex Mixtures, Complex Analyses: an Emphasis on Interpretable Results.
Review in Current environmental health reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Mixture of organic pollutants is associated with cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Everything All at Once: On Choosing an Estimand for Multi-component Environmental Exposures.Epidemiology (Cambridge, Mass.) · 2026Article
- Endocrine-Disrupting Chemicals and Hypertension: Mechanisms and Clinical Implications.Journal of cardiovascular development and disease · 2026Review
- Multiple maternal occupational exposures during pregnancy and newborn size at birth: analysis of the ELFE cohort, a French longitudinal study of children.Scandinavian journal of work, environment & health · 2026Article
- Environmental Mixture-Health Associations: Current Analytical Practice and Reporting Recommendations.China CDC weekly · 2026Article
- Robust environmental exposure pattern recognition and outlier detection with the open-source R package pcpr.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Subgroup analyses and effect modification with Bayesian kernel machine regression.American journal of epidemiology · 2026Article
- Environmental Pollutants and Food Allergy: From Traditional Triggers to Emerging Hazards.Clinical reviews in allergy & immunology · 2026Review
- Associations between prenatal exposure to a mixture of lead, mercury and polychlorinated biphenyls and executive function in Inuit adolescents.Environmental research · 2025Article
- Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- International fluoride symposium: effects of fluoride on human health and its mechanisms of action - a meeting report.BMC proceedings · 2025Article
- TREATMENT EFFECT HETEROGENEITY AND IMPORTANCE MEASURES FOR MULTIVARIATE CONTINUOUS TREATMENTS.The annals of applied statistics · 2025Article
- Applications of mixture methods in epidemiological studies investigating the health impact of persistent organic pollutants exposures: a scoping review.Journal of exposure science & environmental epidemiology · 2025Article
- Metabolic Signatures in Adipose Tissue Linking Lipophilic Persistent Organic Pollutant Mixtures to Blood Pressure Five Years After Bariatric Surgery Among Adolescents.Environmental science & technology · 2025Article
- Exposome Burden Scores to Summarize Environmental Chemical Mixtures: Creating a Fair and Common Scale for Cross-study Harmonization, Report-back and Precision Environmental Health.Current environmental health reports · 2025Review
- Air Pollution and Temperature in Seizures and Epilepsy: A Scoping Review of Epidemiological Studies.Current environmental health reports · 2024Article
- Cross-Cohort Mixture Analysis: A Data Integration Approach With Applications on Gestational Age and DNA-Methylation-Derived Gestational Age Acceleration Metrics.Biometrical journal. Biometrische Zeitschrift · 2024Article
- The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults: A proof-of-concept study.The Science of the total environment · 2024Article
- Towards the prediction of drug solubility in binary solvent mixtures at various temperatures using machine learning.Journal of cheminformatics · 2024Article
- High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage.Environmental science & technology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewThe purpose of this review is to outline the main questions in environmental mixtures research and provide a non-technical explanation of novel or advanced methods to answer these questions. RECENT
findingsMachine learning techniques are now being incorporated into environmental mixture research to overcome issues with traditional methods. Though some methods perform well on specific tasks, no method consistently outperforms all others in complex mixture analyses, largely because different methods were developed to answer different research questions. We discuss four main questions in environmental mixtures research: (1) Are there specific exposure patterns in the study population? (2) Which are the toxic agents in the mixture? (3) Are mixture members acting synergistically? And, (4) what is the overall effect of the mixture? We emphasize the importance of robust methods and interpretable results over predictive accuracy. We encourage collaboration with computer scientists, data scientists, and biostatisticians in future mixture method development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.