ReviewMolecular diagnosis & therapy2019
Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase.
Review in Molecular diagnosis & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Anti-inflammatory and antioxidant effects of salidroside in diabetic nephropathy: a systematic review and meta-analysis of preclinical studies.Frontiers in pharmacology · 2026Pooled it
- Potential effect of tropical fruits Phyllanthus emblica L. for the prevention and management of type 2 diabetic complications: a systematic review of recent advances.European journal of nutrition · 2021Pooled it
- Review
- The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus.Archives of pharmacal research · 2024Review
- Comprehensive machine learning models for predicting therapeutic targets in type 2 diabetes utilizing molecular and biochemical features in rats.Frontiers in endocrinology · 2024Article
- Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs.BMC cancer · 2023Article
- Phenolic Compounds ofInternational journal of molecular sciences · 2023Review
- Effect ofFood technology and biotechnology · 2023Article
- Antidiabetic Properties of Plant Secondary Metabolites.Metabolites · 2023Review
- Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden Root Products via High-Performance Thin-Layer Chromatography, Planar Assays, and High-Resolution Mass Spectrometry.Molecules (Basel, Switzerland) · 2023Article
- Phytosterols in rice bran and their health benefits.Frontiers in nutrition · 2023Review
- Discovery of human pancreatic lipase inhibitors from root ofJournal of pharmaceutical analysis · 2022Article
- Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases.Frontiers in pharmacology · 2022Review
- Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.Oxidative medicine and cellular longevity · 2021Article
- Antioxidant Effects of Salidroside in the Cardiovascular System.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Salidroside prevents tumor necrosis factor-α-induced vascular inflammation by blocking mitogen-activated protein kinase and NF-κB signaling activation.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the Rhodiola root. Recently, various studies have suggested that Rhodiola and salidroside may have pharmacological properties that could be used in the treatment of diabetes, as studies have confirmed that AMP-activated protein kinase (AMPK) and AMPK-related signaling are connected with its beneficial effects. This review aims to summarize the research progress of Rhodiola and salidroside in the treatment of diabetes. A detailed summary of AMPK and AMPK-related signaling induced by Rhodiola and salidroside are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.