ArticleJournal of gastrointestinal cancer2020
Chemical Composition and Antimicrobial and Cytotoxic Activities of Foeniculum vulgare Mill Essential Oils.
Article in Journal of gastrointestinal cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
- Clinical Potential of Essential Oils: Cytotoxicity, Selectivity Index and Antimicrobial Activity Against Gram-Negative ESKAPEE Pathogens.Antibiotics (Basel, Switzerland) · 2026Review
- Clinical Potential of Essential Oils: Cytotoxicity, Selectivity Index, and Efficacy for Combating Gram-Positive ESKAPE Pathogens.Molecules (Basel, Switzerland) · 2025Review
- The Effects of Fennel Essential Oil Supplementation on Mitigating the Heat Stress Impacts on Growth Rate, Blood Biochemical Parameters, and Liver Histopathology in Broiler Chickens.Veterinary sciences · 2025Article
- Phytochemical characterization and bioinformatics guided evaluation of antioxidant and cytotoxic effects of Psoralea bituminosa.Scientific reports · 2025Article
- Spices and culinary herbs for the prevention and treatment of breast cancer: A comprehensive review with mechanistic insights.Cancer pathogenesis and therapy · 2025Review
- The Impact of Dietary Encapsulated Fennel Seed (Foeniculum vulgare Mill.) Essential Oil Inclusion Levels on Performance, Serum Hormone Profiles, and Expression of Reproductive Axis-Related Genes in the Early and Late Laying Phases of Hens.Veterinary medicine and science · 2025Article
- Identification and expression profiling of microRNAs in leaf tissues ofPlant signaling & behavior · 2024Article
- Comparative Study of Essential Oils Extracted FromFood science & nutrition · 2024Article
- Antimicrobial Properties of Fennel By-Product Extracts and Their Potential Applications in Meat Products.Antibiotics (Basel, Switzerland) · 2024Article
- Biological Potential and Essential Oil Profile of Two Wild Apiaceae Species from Algeria (Molecules (Basel, Switzerland) · 2024Article
- Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain.Plants (Basel, Switzerland) · 2024Article
- Dietary encapsulated fennel seed (Foeniculum vulgare Mill.) essential oil supplementation improves performance, modifies the intestinal microflora, morphology, and transcriptome profile of broiler chickens.Journal of animal science · 2024Article
- Fennel Essential Oil as a Complementary Therapy in the Management of Diabetes.Pharmaceutics · 2023Article
- Chemical Evaluation,Molecules (Basel, Switzerland) · 2022Article
- Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation.Biomedicines · 2022Review
- AnMolecules (Basel, Switzerland) · 2022Article
- Nanoemulsion as an Effective Inhibitor of Biofilm-forming Bacterial Associated Drug Resistance: An Insight into COVID Based Nosocomial Infections.Biotechnology and bioprocess engineering : BBE · 2022Review
- Validation of a method of broth microdilution for the determination of antibacterial activity of essential oils.BMC research notes · 2021Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimFoeniculum vulgare (F. vulgare) Mill, commonly known as fennel, belongs to the Umbelliferae (Apiaceae) family, biennial or perennial herbs disseminated in Mediterranean region and central Europe. This herbal medicine (HM) is considered as a traditional HM, and its parts have been studied.
methodsIn this survey, essential oils from seeds collected from three various regions (Kerman, Golestan, and East Azerbaijan Provinces) of Iran were prepared with hydro-distillation and their components were analyzed with gas chromatography (GC) and chromatography time-of-flight mass spectrometry (GC/MS). Antimicrobial and cytotoxic activities of the essential oils were examined with disk-diffusion method on Muller-Hinton agar and Subaru-dextrose Agar, respectively. Additionally, the MTT assay was assessed on breast cancer cell line (MCF-7). The expression of apoptosis-related genes, Bax and Bcl2, was determined using quantitative real-time PCR (RT-qPCR).
resultsThe major fractions of essential oils identified by GC and GC/MS included trans-anethole (78.47%, 49.64%, 78.68%), fenchone (10.5%, 8.4%, and 10.2%), and limonene (5.9%, 6.70%, and 5.6%), respectively. Fennel oil collected from three various places exerted inhibitory effects on the bacterial growth and higher cytotoxic effects on MCF-7 cancer cell line. In addition, the essential oil increased the expression of Bax, but decreased Bcl2 gene expression significantly (P < 0.001).
conclusionAccording to our findings, F. vulgare essential oil can be considered as a promising agent opening venues for novel antimicrobial and anticancer therapies. Owing to side effects and expensiveness of chemotherapy approaches, HM is a new remarkable insight for future therapies.
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