Evidence map›Paper›PMID 31069618›Full record

ArticleJournal of autism and developmental disorders2019

A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder.

Luke Bloy, Kobey Shwayder, Lisa Blaskey, Timothy P L Roberts, David Embick

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luke BloyDepartment of Radiology, Lurie Family Foundations MEG Imaging Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. bloyl@email.chop.edu.ORCID http://orcid.org/0000-0001-5061-851X
Kobey ShwayderDepartment of Radiology, Lurie Family Foundations MEG Imaging Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Lisa BlaskeyDepartment of Radiology, Lurie Family Foundations MEG Imaging Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Timothy P L RobertsDepartment of Radiology, Lurie Family Foundations MEG Imaging Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.
David EmbickDepartment of Linguistics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3M
Electrophysiological Signatures of Language Impairment in Autism Spectrum DisordeR01DC008871 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2007 to 2018
$3.6M
Magnetoencephalographic studies of lexical processing and abstraction in autismR01HD073258 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI EMBICK, DAVID · 2012 to 2016
$1.5M
MEG Imaging Techniques for Low-Functioning Pediatric PopulationsK01MH108762 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BLOY, LUKE · 2016 to 2019
$697k
National Institutes of Health K01MH108762National Institutes of Health R01DC008871National Institutes of Health R01HD073258National Institutes of Health U54HD086984NICHD NIH HHS R01 HD073258NICHD NIH HHS U54 HD086984NIDCD NIH HHS R01 DC008871NIMH NIH HHS K01 MH108762
6 · The paper itself

Abstract

This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5-20 Hz band during 0.2-1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. The measure does not appear related to general cognitive ability nor autism symptom severity (beyond degree of language impairment). We suggest that this oscillatory brain activity indexes lexical search and thus increases with increased search in the mental lexicon. While specificity for language impairment in ASD remains to be determined, such an objective index has potential utility in low functioning individuals with ASD and young children during language acquisition.

Indexed as

Acoustic StimulationAutism Spectrum DisorderChildChild, PreschoolCortical SynchronizationEvoked PotentialsFemaleHumansLanguage DevelopmentLanguage Development DisordersMagnetoencephalographyMaleLanguage impairmentLexical accessMagnetoencephalography (MEG)Oscillation

Identifiers

PMID31069618
PMCPMC6625831
OpenAlexW2944450772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.