ArticleBiomechanics and modeling in mechanobiology2019
Mechanical stresses associated with flattening of human femoropopliteal artery specimens during planar biaxial testing and their effects on the calculated physiologic stress-stretch state.
Article in Biomechanics and modeling in mechanobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Computational Optimization of a Stent for the Femoropopliteal Artery.Annals of biomedical engineering · 2026Article
- EXPERIMENTAL CHARACTERIZATION OF BALLOON ANGIOPLASTY IN HUMAN FEMOROPOPLITEAL ARTERIES WITH DIFFERENT CALCIUM BURDENS.bioRxiv : the preprint server for biology · 2025Article
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Large animal model of controlled peripheral artery calcification.Acta biomaterialia · 2025Article
- Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model.JVS-vascular science · 2025Article
- A viscoelastic constitutive framework for aging muscular and elastic arteries.Acta biomaterialia · 2024Article
- An optimized differential evolution algorithm for constitutive model fitting of arteries.Acta mechanica · 2024Article
- Mechanical, structural, and morphological differences in the iliac arteries.Journal of the mechanical behavior of biomedical materials · 2024Article
- Structural and Mechanical Properties of Human Superficial Femoral and Popliteal Arteries.Annals of biomedical engineering · 2024Review
- Mechanical, structural, and physiologic differences between above and below-knee human arteries.Acta biomaterialia · 2024Article
- Variability in structure, morphology, and mechanical properties of the descending thoracic and infrarenal aorta around their circumference.Journal of the mechanical behavior of biomedical materials · 2024Article
- A viscoelastic constitutive model for human femoropopliteal arteries.Acta biomaterialia · 2023Article
- A method of assessing peripheral stent abrasiveness under cyclic deformations experienced during limb movement.Acta biomaterialia · 2022Article
- A fluid-structure interaction model accounting arterial vessels as a key part of the blood-flow engine for the analysis of cardiovascular diseases.Frontiers in bioengineering and biotechnology · 2022Article
- Compression of the vascular wall to create a friction fit in a vascular anastomotic coupler.Journal of the mechanical behavior of biomedical materials · 2021Article
- Constitutive modeling using structural information on collagen fiber direction and dispersion in human superficial femoral artery specimens of different ages.Acta biomaterialia · 2021Article
- Comparison of morphometric, structural, mechanical, and physiologic characteristics of human superficial femoral and popliteal arteries.Acta biomaterialia · 2021Article
- An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions.Scientific reports · 2021Article
- Mechanical, structural, and physiologic differences in human elastic and muscular arteries of different ages: Comparison of the descending thoracic aorta to the superficial femoral artery.Acta biomaterialia · 2021Article
- Mechanical and structural changes in human thoracic aortas with age.Acta biomaterialia · 2020Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Planar biaxial testing is commonly used to characterize the mechanical properties of arteries, but stresses associated with specimen flattening during this test are unknown. We quantified flattening effects in human femoropopliteal arteries (FPAs) of different ages and determined how they affect the calculated arterial physiologic stress-stretch state. Human FPAs from 472 tissue donors (age 12-82 years, mean 53 ± 16 years) were tested using planar biaxial extension, and morphometric and mechanical characteristics were used to assess the flattening effects. Constitutive parameters for the invariant-based model were adjusted to account for specimen flattening and used to calculate the physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy for the FPAs in seven age groups. Flattened specimens were overall 12 ± 4% stiffer longitudinally and 19 ± 11% stiffer circumferentially when biaxially tested. Differences between the stress-stretch curves adjusted and non-adjusted for the effects of flattening were relatively constant across all age groups longitudinally, but increased with age circumferentially. In all age groups, these differences were smaller than the intersubject variability. Physiologic stresses, stretches, axial force, circumferential stiffness, and stored energy were all qualitatively and quantitatively similar when calculated with and without the flattening effects. Stresses, stretches, axial force, and stored energy reduced with age, but circumferential stiffness remained relatively constant between 25 and 65 years of age suggesting a homeostatic target of 0.75 ± 0.02 MPa. Flattening effects associated with planar biaxial testing are smaller than the intersubject variability and have little influence on the calculated physiologic stress-stretch state of human FPAs.
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