ArticleMetabolomics : Official journal of the Metabolomic Society2019
A
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Advances in postmortem interval estimation: A systematic review of machine learning and metabolomics across various tissue types.Forensic science, medicine, and pathology · 2025Pooled it
- Raman mapping on Ag-covered nanostructured substrates as an innovative approach for rapid estimation of post-mortem interval on human whole blood.International journal of legal medicine · 2026Article
- FTIR Spectroscopy of Vitreous Humor for Postmortem Interval Estimation: A Multivariate Regression Approach.International journal of molecular sciences · 2026Article
- Soil microbial gene expression over one year of human decomposition.FEMS microbiology ecology · 2026Article
- Recent Advances in Forensic Medicine at the Horizon of Omics Sciences and New Biomarkers for Postmortem Interval Estimation.Maedica · 2025Review
- Cytoprotective Compounds in the Primate Eye: Baseline Metabolomic Profiles ofInternational journal of molecular sciences · 2025Article
- Exploratory Metabolomic Fingerprinting of Aqueous Humor in Healthy Horses and Donkeys, and in Horses with Ocular Pathologies.Animals : an open access journal from MDPI · 2025Article
- Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Toward Power Analysis for Partial Least Squares-Based Methods.Biometrical journal. Biometrische Zeitschrift · 2025Article
- A fundamental study on postmortem submersion interval estimation by metabolomics analyzing of gastrocnemius muscle from submersed rat models in freshwater.International journal of legal medicine · 2024Article
- The metabolic clock of ketamine abuse in rats by a machine learning model.Scientific reports · 2024Article
- Postmortem metabolomics: influence of time since death on the level of endogenous compounds in human femoral blood. Necessary to be considered in metabolome study planning?Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Metabolomics investigation of post-mortem human pericardial fluid.International journal of legal medicine · 2023Article
- PMI estimation through metabolomics and potassium analysis on animal vitreous humour.International journal of legal medicine · 2023Article
- Article
- Preliminary Investigation of the Effect of Maceration Procedures on Bone Metabolome and Lipidome.Metabolites · 2022Article
- The Influence of Eyelid Position and Environmental Conditions on the Corneal Changes in Early Postmortem Interval: A Prospective, Multicentric OCT Study.Diagnostics (Basel, Switzerland) · 2022Article
- A preliminary study on early postmortem submersion interval (PMSI) estimation and cause-of-death discrimination based on nontargeted metabolomics and machine learning algorithms.International journal of legal medicine · 2022Article
- The Importance of BHB Testing on the Post-Mortem Diagnosis of Ketoacidosis.Biomolecules · 2021Article
- The Application of Metabolomics in Forensic Science with Focus on Forensic Toxicology and Time-of-Death Estimation.Metabolites · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe estimation of the time since death, or post-mortem interval (PMI), still remains a main conundrum in forensic science. Several approaches have been so far proposed from either a qualitative or a quantitative point of view, but they still lack reliability and robustness. Recently, metabolomics has shown to be a potential tool to investigate the time-related post-mortem metabolite modifications in animal models.
objectivesHere we propose, for the first time, the use of a
methodsAH samples were collected at different times after death (from 118 to 1429 min).
resultsA multivariate calibration model was built to estimate PMI on the basis of the metabolite content of the samples. The model was validated with an independent test set, obtaining a prediction error of 59 min for PMI < 500 min, 104 min for PMI from 500 to 1000 min, and 118 min for PMI > 1000 min. Moreover, the metabolomic approach suggested a picture of the mechanisms underlying the post-mortem biological modifications, highlighting the role played by taurine, choline, and succinate.
conclusionThe time-related modifications of the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.