Evidence map›Paper›PMID 31069461›Full record

ReviewWorld journal of urology2020

Engineering of erectile tissue: the state and future of corporal restoration.

Jyoti D Chouhan, Parth U Thakker, Ryan P Terlecki

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Tissue Engineering for Penile Reconstruction.Bioengineering (Basel, Switzerland) · 2024
    Review
  2. Is regenerative medicine the future of urology?World journal of urology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jyoti D ChouhanDepartment of Urology, Wake Forest Baptist Health, 1 Medical Center Drive, Winston-Salem, NC, 27157, USA.ORCID http://orcid.org/0000-0001-8977-3322
Parth U ThakkerDepartment of Urology, Wake Forest Baptist Health, 1 Medical Center Drive, Winston-Salem, NC, 27157, USA.
Ryan P TerleckiDepartment of Urology, Wake Forest Baptist Health, 1 Medical Center Drive, Winston-Salem, NC, 27157, USA. rterlecki@wakehealth.edu.
Atrium Health Wake Forest Baptist · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide an overview of the state of tissue engineering relative to male erectile tissue and the implications for treatment of penile pathology.

methodsA PubMed review of the relevant peer-reviewed literature pertaining to engineering of penile tissues was performed.

resultsThere are multiple pathologies that threaten form and/or function of the penis. Management of disease rarely offers a path to true restoration. Historical efforts to correct structural defects have largely relied on synthetic materials, commercially prepared allograft or xenograft constructs, or autologous tissue substitutes. These approaches have traditionally suffered from less-than-optimal clinical outcomes and degrees of patient morbidity that may be preventable. Prior work in tissue engineering of corpora cavernosa has demonstrated the ability to produce functional tissue in small and large animal models. A human clinical trial is currently underway.

conclusionsVaried conditions pathologically affecting the penis warrant development of more sophisticated tissue-based solutions. Animal models have demonstrated efficacy in restoring functional corpora cavernosa, and upcoming clinical trials will serve to determine safety and efficacy in humans.

Indexed as

Tissue EngineeringAnimalsForecastingHumansMalePenile ErectionPenisCorpora cavernosaErectile dysfunctionPeyronie’s diseaseStem cellTissue engineering

Identifiers

PMID31069461
OpenAlexW2944075349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.