SynthesisJournal of pediatric psychology2019
Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis.
Synthesis in Journal of pediatric psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Improving self-management in adolescents with sickle cell disease.Pediatric blood & cancer · 2020Trial
- Prioritizing Neurocognitive and Psychosocial Outcomes in Adults With Congenital Heart Disease: A Consensus Statement From the Adults With Congenital Heart Disease/Neuro 2024 Conference.Journal of the American Heart Association · 2026Article
- Childhood Neurocognitive Outcomes in Patients With Fontan Circulation.Journal of the American Heart Association · 2025Article
- Long-term neurodevelopmental outcomes in children with hypoplastic left heart syndrome.Annals of medicine and surgery (2012) · 2025Review
- Mitotic block and epigenetic repression underlie neurodevelopmental defects and neurobehavioral deficits in congenital heart disease.Nature communications · 2025Article
- Association of preoperative cerebral oxygenation with concurrent neurobehavioral scores in term neonates with congenital heart disease compared to healthy controls.Frontiers in pediatrics · 2025Article
- Cognitive Functioning in Children and Young People with Congenital Heart Disease: A Systematic Review of Meta-Analyses.Healthcare (Basel, Switzerland) · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Morbidities After Cardiac Surgery: Impact on Children's Quality of Life and Parents' Mental Health.The Annals of thoracic surgery · 2021Article
- Cognitive and Attentional Function in Children with Hypoplastic Left Heart Syndrome: A Pilot Study.Journal of clinical psychology in medical settings · 2021Article
- Cognitive training in children with hypoplastic left heart syndrome: A pilot randomized trial.Progress in pediatric cardiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDespite surgical palliation, children with hypoplastic left heart syndrome (HLHS) have compromised cardiac functioning and increased risk for cognitive deficits. We quantitatively reviewed the empirical data from this literature.
methodsThe present meta-analysis included 13 studies reporting cognitive function for children with HLHS between the ages of 2 years and 6 months and 17 years that used standardized assessments of Full Scale IQ (FSIQ), Verbal IQ (VIQ), and Performance IQ (PIQ). Differences in cognitive function were assessed relative to normative data, and we examined sample mean age and publication year as moderators.
resultsLarge effects were found for FSIQ (g = -.87, 95% CI [-1.10, -.65], M = 86.88) and PIQ (g = -.89, 95% CI [-1.11, -.68], M = 86.56), and a medium effect was found for VIQ (g = -.61, 95% CI [-.84, -.38], M = 90.82). All models demonstrated significant heterogeneity. Meta-regression analyses of effect size via Hedges' g on child age revealed a significant effect on FSIQ (coefficient = -.07, 95% CI [-.12, -.01], p < .01, R2 = .40) indicating a loss of 1.1 FSIQ points across studies with each increased year of mean sample age.
conclusionsDeficits in FSIQ may reflect chronic brain injury or failure to make expected gains as children age. This review highlights the importance of early intervention in this population, and the need for longitudinal studies analyzing more specific domains of cognitive function and potential moderators.
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