Evidence map›Paper›PMID 31069333›Full record

ReviewAPL bioengineering2019

Challenges and opportunities in exosome research-Perspectives from biology, engineering, and cancer therapy.

Xia Li, Alexander L Corbett, Erfan Taatizadeh, Nishat Tasnim, Jonathan P Little, Cathie Garnis, Mads Daugaard, Emma Guns, Mina Hoorfar, Isaac T S Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in APL bioengineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 311 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
311citing papers in PubMed, 5 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

311 citing papers in PubMed, 5 syntheses or guidelines pooled it, 535 citations in OpenAlex.

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  16. Hypothalamic wars: the last nanodelivery.Reviews in endocrine & metabolic disorders · 2026
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251 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xia LiDepartment of Chemistry, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.
Alexander L CorbettDepartment of Chemistry, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.ORCID https://orcid.org/0000-0003-1968-5612
Erfan Taatizadeh
Nishat TasnimSchool of Engineering, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.ORCID https://orcid.org/0000-0002-9899-2014
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.
Cathie GarnisDepartment of Integrative Oncology, BC Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada, and Department of Surgery, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
Mads DaugaardVancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada, and Department of Urologic Sciences, University of British Columbia, Vancouver, Vancouver, BC V5Z 1M9, Canada.
Emma GunsVancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada, and Department of Urologic Sciences, University of British Columbia, Vancouver, Vancouver, BC V5Z 1M9, Canada.
Mina HoorfarSchool of Engineering, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.
Isaac T S LiDepartment of Chemistry, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada.ORCID https://orcid.org/0000-0002-8450-5326
BC Cancer Agency · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small (∼30-140 nm) lipid bilayer-enclosed particles of endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most cell types. There has been growing interest in exosome research in the last decade due to their emerging role as intercellular messengers and their potential in disease diagnosis. Indeed, exosomes contain proteins, lipids, and RNAs that are specific to their cell origin and could deliver cargo to both nearby and distant cells. As a result, investigation of exosome cargo contents could offer opportunities for disease detection and treatment. Moreover, exosomes have been explored as natural drug delivery vehicles since they can travel safely in extracellular fluids and deliver cargo to destined cells with high specificity and efficiency. Despite significant efforts made in this relatively new field of research, progress has been held back by challenges such as inefficient separation methods, difficulties in characterization, and lack of specific biomarkers. In this review, we summarize the current knowledge in exosome biogenesis, their roles in disease progression, and therapeutic applications and opportunities in bioengineering. Furthermore, we highlight the established and emerging technological developments in exosome isolation and characterization. We aim to consider critical challenges in exosome research and provide directions for future studies.

Identifiers

PMID31069333
PMCPMC6481742
OpenAlexW2926623862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.