Evidence map›Paper›PMID 31069310›Full record

ArticleAPL bioengineering2018

Rationally engineered advances in cancer research.

Adam J Engler, Dennis E Discher

Abstract read
In one paragraph

Article in APL bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dennis E DischerBiophysical Engineering Labs, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Funding

PSOC@Penn Education and OutreachU54CA193417 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2015 to 2020
$10.5M
Carrier Shape Matters: Filomicelles, Long-circulation, and the EPR effectR01EB007049 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2006 to 2014
$2.8M
Nuclear Mechanics varies with Tissue Mechanics & Regulates CytoskeletonR21HL128187 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2015 to 2016
$426k
NCI NIH HHS U54 CA193417NHLBI NIH HHS R21 HL128187NIBIB NIH HHS R01 EB007049
6 · The paper itself

Abstract

The physical and engineering sciences have much to offer in understanding, diagnosing, and even treating cancer. Microfluidics, imaging, materials, and diverse measurement devices are all helping to shift paradigms of tumorigenesis and dissemination. Using materials and micro-probes of elasticity, for example, epithelia have been shown to transform into mesenchymal cells when the elasticity of adjacent tissue increases. Approaches common in engineering science enable such discoveries, and further application of such tools and principles will likely improve existing cancer models

Identifiers

PMID31069310
PMCPMC6481711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.