ArticleAPL bioengineering2018
Critical roles of time-scales in soft tissue growth and remodeling.
Article in APL bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Mechanisms driving thoracic aortic aneurysm instability.Biomechanics and modeling in mechanobiology · 2026Article
- Mechanisms Driving Thoracic Aortic Aneurysm Stability.bioRxiv : the preprint server for biology · 2025Article
- Strategies for Development of Synthetic Heart Valve Tissue Engineering Scaffolds.Progress in materials science · 2023Article
- About prestretch in homogenized constrained mixture models simulating growth and remodeling in patient-specific aortic geometries.Biomechanics and modeling in mechanobiology · 2022Article
- Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity.Nature reviews. Cardiology · 2021Review
- Complementary roles of mechanotransduction and inflammation in vascular homeostasis.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- Implantable biorobotic organs.APL bioengineering · 2020Article
- Cardiovascular patient-specific modeling: Where are we now and what does the future look like?APL bioengineering · 2020Article
- Numerical knockouts-In silico assessment of factors predisposing to thoracic aortic aneurysms.PLoS computational biology · 2020Article
- Vascular adaptation in the presence of external support - A modeling study.Journal of the mechanical behavior of biomedical materials · 2020Article
- Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms.Current opinion in biomedical engineering · 2020Review
- Fast, Rate-Independent, Finite Element Implementation of a 3D Constrained Mixture Model of Soft Tissue Growth and Remodeling.Computer methods in applied mechanics and engineering · 2020Article
- Computational Study of Growth and Remodeling in Ascending Thoracic Aortic Aneurysms Considering Variations of Smooth Muscle Cell Basal Tone.Frontiers in bioengineering and biotechnology · 2020Article
- Three-dimensional numerical simulation of soft-tissue wound healing using constrained-mixture anisotropic hyperelasticity and gradient-enhanced damage mechanics.Journal of the Royal Society, Interface · 2020Article
- Computational Modeling Predicts Immuno-Mechanical Mechanisms of Maladaptive Aortic Remodeling in Hypertension.International journal of engineering science · 2019Article
- Mechanobiological Stability of Biological Soft Tissues.Journal of the mechanics and physics of solids · 2019Article
- Modeling mechano-driven and immuno-mediated aortic maladaptation in hypertension.Biomechanics and modeling in mechanobiology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Most soft biological tissues exhibit a remarkable ability to adapt to sustained changes in mechanical loads. These macroscale adaptations, resulting from mechanobiological cellular responses, are important determinants of physiological behaviors and thus clinical outcomes. Given the complexity of such adaptations, computational models can significantly increase our understanding of how contributions of different cell types or matrix constituents, and their rates of turnover and evolving properties, ultimately change the geometry and biomechanical behavior at the tissue level. In this paper, we examine relative roles of the rates of tissue responses and external loading and present a new rate-independent approach for modeling the evolution of soft tissue growth and remodeling. For illustrative purposes, we also present numerical results for arterial adaptations. In particular, we show that, for problems defined by particular characteristic times, this approximate theory captures well the predictions of a fully general constrained mixture theory at a fraction of the computational cost.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.