Evidence map›Paper›PMID 31069302›Full record

ArticleAPL bioengineering2018

Non-steric-zipper models for pathogenic α-synuclein conformers.

Brock Schuman, Amy Won, Koroboshka Brand-Arzamendi, James B Koprich, Xiao-Yan Wen, Patrick A Howson, Jonathan M Brotchie, Christopher M Yip

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Brock SchumanSt. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
Amy WonInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
Koroboshka Brand-ArzamendiSt. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
James B KoprichKrembil Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada.
Xiao-Yan WenSt. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
Patrick A HowsonKrembil Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada.
Jonathan M BrotchieKrembil Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada.
Christopher M YipInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
St. Michael's Hospital · CAToronto Western Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease neurodegenerative brain tissue exhibits two biophysically distinct α-synuclein fiber isoforms-single stranded fibers that appear to be steric-zippers and double-stranded fibers with an undetermined structure. Herein, we describe a β-helical homology model of α-synuclein that exhibits stability in probabilistic and Monte Carlo simulations as a candidate for stable prional dimer conformers in equilibrium with double-stranded fibers and cytotoxic pore assemblies. Molecular models of β-helical pore assemblies are consistent with α-synuclein

Identifiers

PMID31069302
PMCPMC6481714
OpenAlexW2799310372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.