ArticleAPL bioengineering2018
Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis.
Article in APL bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy.Advanced healthcare materials · 2025Article
- Porous PLLA microspheres dispersed in HA/collagen hydrogel as injectable facial fillers to enhance aesthetic effects.Regenerative biomaterials · 2025Article
- Quantitative Evaluation of the Pore and Window Sizes of Tissue Engineering Scaffolds on Scanning Electron Microscope Images Using Deep Learning.ACS omega · 2024Article
- Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Capturing cerium ions via hydrogel microspheres promotes vascularization for bone regeneration.Materials today. Bio · 2024Article
- Elastomeric Porous Poly(glycerol sebacate) Methacrylate (PGSm) Microspheres as 3D Scaffolds for Chondrocyte Culture and Cartilage Tissue Engineering.International journal of molecular sciences · 2023Article
- Construction of PLGA Porous Microsphere-Based Artificial Pancreatic Islets Assisted by the Cell Centrifugation Perfusion Technique.ACS omega · 2023Article
- Development of PCL PolyHIPE Substrates for 3D Breast Cancer Cell Culture.Bioengineering (Basel, Switzerland) · 2023Article
- Gelatin-containing porous polycaprolactone PolyHIPEs as substrates for 3D breast cancer cell culture and vascular infiltration.Frontiers in bioengineering and biotechnology · 2023Article
- Porous Crosslinked Zwitterionic Microparticles Based on Glycidyl Methacrylate and N-Vinylimidazole as Possible Drug Delivery Systems.International journal of molecular sciences · 2022Article
- Development of In Situ Microfluidic System for Preparation of Controlled Porous Microsphere for Tissue Engineering.Pharmaceutics · 2022Article
- Microvascular Experimentation in the Chick Chorioallantoic Membrane as a Model for Screening Angiogenic Agents including from Gene-Modified Cells.International journal of molecular sciences · 2021Review
- Fundamentals and Design-Led Synthesis of Emulsion-Templated Porous Materials for Environmental Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Hierarchically Porous Microspheres by Thiol-ene Photopolymerization of High Internal Phase Emulsions-in-Water Colloidal Systems.Polymers · 2021Article
- Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles.Polymers · 2021Article
- Porous Polymers from High Internal Phase Emulsions as Scaffolds for Biological Applications.Polymers · 2021Review
- Preparation and characterization of ethylcellulose microspheres for sustained-release of pregabalin.Research in pharmaceutical sciences · 2021Article
- Considerations Using Additive Manufacture of Emulsion Inks to Produce Respiratory Protective Filters Against Viral Respiratory Tract Infections Such as the COVID-19 Virus.International journal of bioprinting · 2021Article
- Comparison of the Anabolic Effects of Reported Osteogenic Compounds on Human Mesenchymal Progenitor-derived Osteoblasts.Bioengineering (Basel, Switzerland) · 2020Article
- Design and Evaluation of an Osteogenesis-on-a-Chip Microfluidic Device Incorporating 3D Cell Culture.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porous microspheres have the potential for use as injectable bone fillers to obviate the need for open surgery. Successful bone fillers must be able to support vascularisation since tissue engineering scaffolds often cease functioning soon after implantation due to a failure to vascularise rapidly. Here, we test the angiogenic potential of a tissue engineered bone filler based on a photocurable acrylate-based high internal phase emulsion (HIPE). Highly porous microspheres were fabricated via two processes, which were compared. One was taken forward and investigated for its ability to support human mesenchymal progenitor cells and angiogenesis in a chorioallantoic membrane (CAM) assay. Porous microspheres with either a narrow or broad size distribution were prepared via a T-junction microfluidic device or by a controlled stirred-tank reactor of the HIPE water in oil in water (w/o/w), respectively. Culture of human embryonic stem cell-derived mesenchymal progenitor (hES-MP) cells showed proliferation over 11 days and formation of cell-microsphere aggregates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.