Evidence map›Paper›PMID 31069263›Full record

ArticleCommunications biology2019

Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABA

Adolfo Sequeira, Kevin Shen, Assaf Gottlieb, Agenor Limon

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. RO4938581, a GABAMolecular psychiatry · 2026
    Article
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  6. Review
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  8. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  9. Article
  10. bioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Article
  13. Chemogenetic Modulation of PreopticInternational journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
  16. Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  17. Pathogenicity Prediction of GABAbioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. A Diet Enriched withInternational journal of molecular sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Adolfo Sequeira1Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, CA USA.
Kevin Shen2Department of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch, Galveston, TX USA.
Assaf Gottlieb3School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX USA.
Agenor Limon2Department of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch, Galveston, TX USA.ORCID 0000-0002-6613-770X
The University of Texas Medical Branch at Galveston · USThe University of Texas Health Science Center · USUniversity of California, Irvine · US

Funding

Metallothioneins and polyamines in major depression and suicideR01MH097082 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEQUEIRA, ADOLFO · 2012 to 2015
$1.5M
Synaptic Imbalance in Mild Cognitive Impairment and Alzheimer's DiseaseR21AG053740 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAUTERBORN, JULIE C, LIMON, AGENOR · 2016 to 2017
$425k
Multidimensional Analysis of Synaptic Dysfunction in SchizophreniaR21MH113177 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMON, AGENOR, VAWTER, MARQUIS PHILIP · 2017 to 2018
$425k
NIA NIH HHS R21 AG053740NIMH NIH HHS R01 MH097082NIMH NIH HHS R21 MH113177
6 · The paper itself

Abstract

Altered expression of GABA receptors (GABA

Indexed as

TranscriptomeAdultAmygdalaBrainCerebral CortexCorpus StriatumDatasets as TopicFemaleGene Expression ProfilingHippocampusHumansHypothalamusMaleMesencephalonMiddle AgedOrgan SpecificityProtein SubunitsReceptors, GABA-AIon channels in the nervous systemMicroarrays

Identifiers

PMID31069263
PMCPMC6494906
OpenAlexW2942628203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.