ArticleNPJ Parkinson's disease2019
Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression.
Article in NPJ Parkinson's disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review.Journal of Parkinson's disease · 2025Pooled it
- Sleep Disorders and Cognitive Dysfunctions in Parkinson's Disease: A Meta-Analytic Study.Neuropsychology review · 2021Pooled it
- Pooled it
- Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker-Defined Synucleinopathy.Annals of clinical and translational neurology · 2026Article
- Longitudinal insights from iron accumulation in motor system of prodromal and clinical Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies.Clinics and practice · 2025Review
- Cuneus atrophy and Parkinsonian phenoconversion in cognitively unimpaired patients with isolated REM sleep behavior disorder.Journal of neurology · 2024Article
- Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder.Brain and behavior · 2024Article
- Whole brain pattern of iron accumulation in REM sleep behavior disorder.Human brain mapping · 2024Article
- Cortical and subcortical morphometric changes and their relation to cognitive impairment in isolated REM sleep behavior disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neuroanatomical findings in isolated REM sleep behavior disorder and early Parkinson's disease: a Voxel-based morphometry study.Brain imaging and behavior · 2024Article
- Magnetic Resonance Imaging and Nuclear Imaging of Parkinsonian Disorders: Where do we go from here?Current neuropharmacology · 2024Review
- MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders.Frontiers in aging neuroscience · 2024Article
- Static and dynamic brain morphological changes in isolated REM sleep behavior disorder compared to normal aging.Frontiers in neuroscience · 2024Article
- Network disruption based on multi-modal EEG-MRI in α-synucleinopathies.Frontiers in neurology · 2024Article
- Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review.Brain sciences · 2023Review
- Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies.Brain : a journal of neurology · 2023Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to determine whether structural MRI measures are associated with clinical impairment and progression to a Lewy body disease in patients with idiopathic REM sleep behavior disorder (iRBD). Twenty-seven patients with iRBD in addition to patients with de novo PD and healthy controls were included from the Parkinson's Progression Markers Initiative. Patients with iRBD were followed for up to 3 years. Clinical and MRI measures were compared across groups and the association between clinical features and structural MRI was assessed in iRBD patients. Cox regression analyses were applied to identify risk factors for progressing to a Lewy body disease in iRBD. Our results showed that, at baseline, iRBD patients showed parietal and occipital cortical thinning, compared to controls. They also showed worse motor and non-motor abilities, some of which correlated with motor, frontal or temporal cortical thinning. At follow-up, six (22%) iRBD patients were diagnosed with a Lewy body disorder. These patients showed cortical thinning in frontal, occipital and parietal areas compared to iRBD non-converters. Cortical thinning was a significant predictor for future development of a Lewy body disorder (HR: 0.784; 95% CI: 0.640-0.960; p = 0.02). We conclude that cortical thinning is associated with worse motor and non-motor abilities, and predicts conversion to a Lewy body disorder in iRBD, suggesting it could be used to select candidates for clinical trials to delay the onset of neurodegenerative disease.
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