ArticleSouth Asian journal of cancer
Reproductive factors and breast cancer risk: A meta-analysis of case-control studies in Indian women.
Article in South Asian journal of cancer. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk factors for breast cancer: an umbrella review of observational cohort studies and causal relationship analysis.Frontiers in oncology · 2025Pooled it
- Systematic Review and Meta-Analysis of Lifestyle and Reproductive Factors Associated with Risk of Breast Cancer in Asian Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Pooled it
- Pooled it
- Does marital status correlate with the female breast cancer risk? A systematic review and meta-analysis of observational studies.PloS one · 2020Pooled it
- Barriers to screening amongst first-degree female relatives of patients with breast cancer: a qualitative study.BMC women's health · 2026Article
- ABUS-based glandular tissue component classification for breast cancer risk prediction in Chinese women with dense breasts: a retrospective study.BMC medical imaging · 2026Article
- Low Frequency of Pathogenic Variants in BRCA1 Exons 11/20 and BRCA2 Exon 11 Suggests Divergent Mutational Hotspots in Sudanese Breast Cancer Patients: A Case-Control Study.Breast cancer : basic and clinical research · 2026Article
- Unraveling breast cancer risk with a focus on menopausal status: a large case-control study.Cancer causes & control : CCC · 2025Article
- Sociodemographic Profile, Reproductive Factors and Presentation Pattern in Breast Cancer Patients from North India: A Hospital Based Study.Journal of pharmacy & bioallied sciences · 2025Article
- Exploring breast cancer knowledge, screening practices, needs among rural women, and challenges of community health workers in breast cancer screening in Tamil Nadu: A community-based mixed-method approach.Journal of family medicine and primary care · 2025Article
- Association of lifestyle factors with breast cancer incidence: An overview of systematic reviews.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Potential Risk and Protective Factors in High- and Low-incidence Breast Cancer Populations in Northeast India: A Cross-sectional Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Chronic Treatment with Panax ginseng and Angelica keiskei Decreases Blood Pressure and Improves Endothelial Function in Ovariectomized Rats.Arquivos brasileiros de cardiologia · 2025Article
- Review
- Determinants of breast cancer among women attending oncology units in selected health facilities of Hawassa City, Sidama Region, Southern Ethiopia, 2023: case-control study.Frontiers in oncology · 2024Article
- Breast cancer in young Indian women: factors, challenges in screening, and upcoming diagnostics.Journal of cancer research and clinical oncology · 2023Review
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- The Causal Effect of Reproductive Factors on Breast Cancer: A Two-Sample Mendelian Randomization Study.Journal of clinical medicine · 2023Article
- Modifiable (Sleeping Pattern and Stress) and Non-Modifiable Risk Factors Associated with Breast Cancer: A Matched Case-Control Study in Delhi, India.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Real-World Experience of Treating Young Adult Patients with Breast Cancer from a Single Center in Southern India.South Asian journal of cancer · 2022Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveIndia is the world's most biodiverse region and is undergoing a period of dramatic social and economic change. Due to population's explosion, climate change and lax implementation of environmental policies, the incidence of breast cancer is increasing. From population-based cancer registry data, breast cancer is the most common cancer in women in urban registries where it constitutes more than 30% of all cancers in females. We conducted a meta-analysis of all breast cancer case-control studies conducted in India during 1991-2018 to find pooled estimates of odds ratio (OR). MATERIALS AND
methodsEligible studies were identified through a comprehensive literature search of PubMed, EMBASE, and HINARI databases from 1991 to January 2018. This analysis included 24 observational studies out of 34 that reported the case-control distribution of reproductive factors, body mass index (BMI) and type of residence. The analysis was performed using RevMan 5.3 (Review Manager, 2017) applying the random-effects model.
resultsA total of 21,511 patients (9889 cases and 11,622 controls) were analyzed, resulting in statistically significant association between breast cancer and the following reproductive factors: never breastfeed (OR: 3.69; 95% confidence interval [CI]: 1.70, 8.01), menopausal age >50 years (OR: 2.88; 95% CI: 1.85, 3.85), menarche age <13 years (OR: 1.83; 95% CI: 1.34, 2.51), null parity (OR: 1.58; 95% CI: 1.21, 2.06), postmenopause (OR: 1.35; 95% CI: 1.13, 1.62), and age at the 1
conclusionThe results of this meta-analysis are indicative of significant associations between reproductive factors and breast cancer risk, profoundly so among women experiencing menopause after the age of 50, women who never breastfeed and FH of breast cancer.
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