Evidence map›Paper›PMID 31069118›Full record

ReviewNPJ vaccines2019

Recent advances in the production of recombinant glycoconjugate vaccines.

Emily Kay, Jon Cuccui, Brendan W Wren

Open access · goldAbstract readReview
In one paragraph

Review in NPJ vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 147 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. [Use of vaccines to prevent the development of bacterial resistance].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
    Review
  5. Materials today. Bio · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Fast and accurateMicrobial genomics · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Characterization of Ssc, anJournal of bacteriology · 2024
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily KayDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT UK.
Jon CuccuiDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT UK.
Brendan W WrenDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT UK.ORCID 0000-0002-6140-9489
University of London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G019177/1Medical Research Council MR/K012053/1Wellcome Trust 102979/Z/13/Z
6 · The paper itself

Abstract

Glycoconjugate vaccines against bacteria are one of the success stories of modern medicine and have led to a significant reduction in the global occurrence of bacterial meningitis and pneumonia. Glycoconjugate vaccines are produced by covalently linking a bacterial polysaccharide (usually capsule, or more recently O-antigen), to a carrier protein. Given the success of glycoconjugate vaccines, it is surprising that to date only vaccines against

Indexed as

ImmunologyPathogenesis

Identifiers

PMID31069118
PMCPMC6494827
OpenAlexW2943218646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.