ArticleNPJ systems biology and applications2019
A yield-cost tradeoff governs
Article in NPJ systems biology and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 75 citations in OpenAlex.
- On the conditions for shifts in metabolic strategies.PLoS computational biology · 2026Review
- Priority effects inhibit the repeated evolution of phototrophy.Npj complexity · 2026Article
- Overflow metabolism in bacterial, yeast, and mammalian cells: different names, same game.Molecular systems biology · 2025Review
- Carbon source-dependent transcriptomic regulation and monosaccharide remodeling of exopolysaccharide biosynthesis in Pediococcus pceusentosa LL-07.BMC microbiology · 2025Article
- Cross-feeding percolation phase transitions of intercellular metabolic networks.Science advances · 2025Article
- Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources.mSystems · 2025Article
- A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations.PLoS computational biology · 2025Article
- Carbon Capture and Utilization for Sustainable Supply Chain Design of Intermediate Chemicals: The Formate Factory.ACS sustainable resource management · 2025Article
- The catabolic nature of fermentative substrates influences proteomic rewiring in Escherichia coli under anoxic growth.Microbial cell factories · 2025Article
- Engineering new-to-nature biochemical conversions by combining fermentative metabolism with respiratory modules.Nature communications · 2024Article
- Investigating the Role of β-Disodium Glycerophosphate and Urea in Promoting Growth ofFoods (Basel, Switzerland) · 2024Article
- Emergent Lag Phase in Flux-Regulation Models of Bacterial Growth.Bulletin of mathematical biology · 2023Article
- Functional decomposition of metabolism allows a system-level quantification of fluxes and protein allocation towards specific metabolic functions.Nature communications · 2023Article
- Resource allocation accounts for the large variability of rate-yield phenotypes across bacterial strains.eLife · 2023Article
- Public good-driven release of heterogeneous resources leads to genotypic diversification of an isogenic yeast population.Evolution; international journal of organic evolution · 2022Article
- Intercellular interaction mechanisms promote diversity in intracellular ATP concentration in Escherichia coli populations.Scientific reports · 2022Article
- Relationship between fitness and heterogeneity in exponentially growing microbial populations.Biophysical journal · 2022Article
- Cellular perception of growth rate and the mechanistic origin of bacterial growth law.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess.Microbial cell factories · 2022Article
- Predicting Metabolic Adaptation Under Dynamic Substrate Conditions Using a Resource-Dependent Kinetic Model: A Case Study UsingFrontiers in molecular biosciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Living cells react to changes in growth conditions by re-shaping their proteome. This accounts for different stress-response strategies, both specific (i.e., aimed at increasing the availability of stress-mitigating proteins) and systemic (such as large-scale changes in the use of metabolic pathways aimed at a more efficient exploitation of resources). Proteome re-allocation can, however, imply significant biosynthetic costs. Whether and how such costs impact the growth performance are largely open problems. Focusing on carbon-limited
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.