Evidence map›Paper›PMID 31069062›Full record

ReviewF1000Research2019

Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention.

Shayan Cheraghlou, Young Lim, Keith Choate

Open access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Infantile hemangioma: the common and enigmatic vascular tumor.The Journal of clinical investigation · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shayan CheraghlouDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4382-7828
Young LimDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Keith ChoateDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2176-4822
Yale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Genetics and Pathobiology of Cutaneous Mosaic DisordersR01AR071491 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE · 2018 to 2026
$4.2M
NIAMS NIH HHS R01 AR071491NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras-mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.

Indexed as

ChildEndothelial CellsHumansMAP Kinase Signaling SystemMutationras ProteinsVascular Neoplasmsras Proteinsvascular tumors; vascular tumor management; genetics; hemangioma; Ras; MAPK; GNA14; GNA11; GNAQ; IDH

Identifiers

PMID31069062
PMCPMC6492225
OpenAlexW2943493210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.