Evidence map›Paper›PMID 31069036›Full record

ArticleAddiction & health2018

Effects of Opium Addiction on Some Biochemical Factors in Diabetic Rats.

Gholamreza Asadikaram, Sina Vakili, Hamed Akbari, Marjan Kheirmand-Parizi, Erfan Sadeghi, Majid Asiabanha, Nader Shahrokhi

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In one paragraph

Article in Addiction & health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gholamreza AsadikaramProfessor, Neuroscience Research Center, Institute of Neuropharmacology AND Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Sina VakiliPhD Candidate, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hamed AkbariBiochemist, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Marjan Kheirmand-PariziDentist, Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
Erfan SadeghiPhD Candidate, Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah AND Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Majid AsiabanhaPhD, Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University AND Sarem Fertility and Infertility Research Center AND Sarem Cell Research Center, Sarem Women's Hospital, Tehran, Iran.
Nader ShahrokhiAssociate Professor, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Kerman University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study was carried out aiming to investigate the effects of opium on some biochemical factors in diabetic and non-diabetic male and female rats.

methodsThis experimental study was carried out on 28 male and 28 female Wistar rats. The animals were divided into diabetic addicted (DA), diabetic non-addicted (DNA), non-diabetic addicted (NDA), and non-diabetic non-addicted (NDNA) groups of male and female. A double dose of opium was intraperitoneally administered to the addicted groups. Peripheral blood samples were collected to measure the creatinine, uric acid, cholesterol, triglycerides (TG), total protein, and albumin levels. Three-way analysis of variance (ANOVA) was used to compare the mean levels of biofactors among the study groups.

findingsCholesterol and total protein were significantly affected by opium and sex, but not diabetes condition, such that there was a decrease of cholesterol and total protein levels in opium-addicted rats compared to non-opium-addicted ones. However, uric acid, TG, albumin, and creatinine were not affected by opium and diabetes conditions.

conclusionOpium significantly decreased cholesterol and total protein levels. It could be deduced that the effects of opium on cholesterol and total protein are not sex-dependent, moreover, opium consumption may not have significant effects on biochemical factors in diabetic conditions.

Indexed as

Biochemical markersCholesterolCreatinineDiabetes mellitusOpium addictionTotal protein

Identifiers

PMID31069036
PMCPMC6494983
OpenAlexW2982063410

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.