Evidence map›Paper›PMID 31069028›Full record

ArticleJournal of extracellular vesicles2019

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications.

Kenneth W Witwer, Bas W M Van Balkom, Stefania Bruno, Andre Choo, Massimo Dominici, Mario Gimona, Andrew F Hill, Dominique De Kleijn, Mickey Koh, Ruenn Chai Lai and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 416 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
416citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

416 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  8. Extracellular Vesicles for Corneal Endothelial Repair.International journal of molecular sciences · 2026
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356 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bas W M Van BalkomDivision Internal Medicine and Dermatology, Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Stefania BrunoDepartment of Medical Sciences and Molecular Biotechnology Center, University of Torino, Torino, Italy.
Andre ChooBioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore.
Massimo DominiciMAB Laboratory, TPM of Mirandola, Mirandola, Italy.
Mario GimonaGMP Laboratory, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Research Program Nanovesicular Therapies, Department of Transfusion Medicine and Celericon Therapeutics G.m.b.H., Paracelsus Medical University (PMU), Salzburg, Austria.
Andrew F HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.ORCID 0000-0001-5581-2354
Dominique De KleijnDepartment of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Mickey KohDepartment of Haematology, St George's University Hospital NHS Trust, London, UK.
Ruenn Chai LaiInstitute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore.
S Alex MitsialisDepartment of Pediatrics, Harvard Medical School & Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Luis A OrtizDivision of Environmental and Occupational Medicine, Department of Environmental and Occupational Health, Graduate School of Public Health at the University of Pittsburgh, Pittsburgh, PA, USA.
Eva RohdeGMP Laboratory, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Research Program Nanovesicular Therapies, Department of Transfusion Medicine and Celericon Therapeutics G.m.b.H., Paracelsus Medical University (PMU), Salzburg, Austria.
Takashi AsadaDepartment of Tissue Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Wei Seong TohFaculty of Dentistry, National University of Singapore, Singapore, Singapore.
Daniel J WeissHealth Sciences Research Facility, University of Vermont College of Medicine, Burlington, VT, USA.
Lei ZhengDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Bernd GiebelInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sai Kiang LimInstitute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting rapidly towards clinical applications. However, discrepancies and controversies about the biology, functions, and potency of MSC-sEVs have arisen due to several factors: the diversity of MSCs and their preparation; various methods of sEV production and separation; a lack of standardized quality assurance assays; and limited reproducibility of

Indexed as

DefinitionMSCPlease check whether the inserted Keywords are correctsEVTherapeutics

Identifiers

PMID31069028
PMCPMC6493293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.