ArticleTherapeutic advances in gastroenterology2019
Acute and subacute effects of oropharyngeal sensory stimulation with TRPV1 agonists in older patients with oropharyngeal dysphagia: a biomechanical and neurophysiological randomized pilot study.
Article in Therapeutic advances in gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05720871 (Treatment of Chronic Post-stroke Oropharyngeal Dysphagia With Paired Stimulation Through Peripheral TRVP1 Agonists and Non-invasive Brain Stimulation), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Chronic Post-stroke Oropharyngeal Dysphagia With Paired Stimulation Through Peripheral TRVP1 Agonists and Non-invasive Brain Stimulation
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effects of pharmacological agents for neurogenic oropharyngeal dysphagia: A systematic review and meta-analysis.Neurogastroenterology and motility · 2022Pooled it
- The therapeutic effect of capsaicin on oropharyngeal dysphagia: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Effect of TRP-Stimulating Compounds to Reduce Swallowing Response Time in the Elderly: A Systematic Review.Dysphagia · 2021Pooled it
- Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial.Journal of oral rehabilitation · 2026Trial
- An oral nutritional supplement with TRPM8 agonists as a cooling flavor improved swallowing function in post-stroke patients with oropharyngeal dysphagia.Scientific reports · 2026Trial
- Pharyngo-Esophageal Modulatory Swallow Responses to Bolus Volume and Viscosity Across Time.The Laryngoscope · 2022Trial
- Article
- Article
- The Novel TRPV1 Agonist ST-6631 Improves Swallowing Function in Rat Models of Stroke-Related Dysphagia and Demonstrates Pharmaceutical Advantage Over Capsaicin, by Exhibiting Minimal Pungent and Irritant Properties.Pharmacology research & perspectives · 2026Article
- Review
- Brainstem Stroke and Dysphagia Treatment: A Narrative Review on the Role of Neuromodulation, Skill-Based Swallowing Training and Transient Receptor Potential Agonists.Audiology research · 2025Review
- Post-extubation dysphagia in the ICU-a narrative review: epidemiology, mechanisms and clinical management (Update 2025).Critical care (London, England) · 2025Review
- Topical ATP Application in the Peripheral Swallowing-Related Regions Facilitates Triggering of the Swallowing Reflex Involving P2X3 Receptors.Function (Oxford, England) · 2025Article
- Review
- Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia.The Japanese dental science review · 2023Review
- Gustatory stimulus interventions for older adults with dysphagia: a scoping review.Aging clinical and experimental research · 2023Article
- Pharmacological activation of transient receptor potential vanilloid 4 promotes triggering of the swallowing reflex in rats.Frontiers in cellular neuroscience · 2023Article
- A Comparative Study on the Effect of Acute Pharyngeal Stimulation with TRP Agonists on the Biomechanics and Neurophysiology of Swallow Response in Patients with Oropharyngeal Dysphagia.International journal of molecular sciences · 2022Article
- TRPA1s act as chemosensors but not as cold sensors or mechanosensors to trigger the swallowing reflex in rats.Scientific reports · 2022Article
- Oropharyngeal Dysphagia in Older People is Associated with Reduced Pharyngeal Sensitivity and Low Substance P and CGRP Concentration in Saliva.Dysphagia · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder people with oropharyngeal dysphagia (OD) present a decline in pharyngeal sensory function. The aim of this proof-of-concept study was to assess the biomechanical and neurophysiological effects of acute and subacute oropharyngeal sensory stimulation with transient receptor potential vanilloid 1 (TRPV1) agonists (capsaicinoids) in older patients with OD.
methodsWe studied the effect of a single dose
resultsAcute stimulation by capsaicinoids 10
conclusionsAfter 2 weeks of treatment, oropharyngeal sensory stimulation with capsaicinoids induced cortical changes that were correlated with improvements in swallowing biomechanics in older patients with OD. These results further show that sensory stimulation by TRPV1 agonists can become a useful pharmacological treatment for older patients with OD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.