Evidence map›Paper›PMID 31068934›Full record

ArticleFrontiers in immunology2019

Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Rα Signaling in ICOS

Laila N Abudulai, Sonia Fernandez, Karli Corscadden, Lea-Ann Kirkham, Michael Hunter, Jeffrey J Post, Martyn A French

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Laila N AbudulaiSchool of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
Sonia FernandezSchool of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
Karli CorscaddenWesfarmers Centre for Vaccine and Infectious Disease Research, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.
Lea-Ann KirkhamSchool of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
Michael HunterDepartment of Infectious Diseases, Royal Victoria Hospital, Belfast, United Kingdom.
Jeffrey J PostDepartment of Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, Australia.
Martyn A FrenchSchool of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
University of Western Australia · AUPrince of Wales Hospital · AUThe Kids Research Institute Australia · AUUniversity of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Greater understanding of factors influencing the maturation of antibody responses against pneumococcal polysaccharides (PcPs) may improve pneumococcal vaccination strategies. Although PcPs are type 2 T cell-independent antigens thought not to induce follicular immune responses, we have previously shown that IgG2 antibody responses against antigens in the 23-valent unconjugated PcP vaccine (PPV23) are associated with expansion of ICOS

Indexed as

AdultAntibodies, BacterialAntibody FormationBiomarkersCD4 Lymphocyte CountCoinfectionFemaleHIVHIV InfectionsHumansImmunoglobulin GImmunophenotypingInducible T-Cell Co-Stimulator ProteinMalePneumococcal InfectionsPneumococcal Vaccines23-valent pneumococcal capsular polysaccharide vaccineAntibodies, BacterialBiomarkersICOS protein, humanImmunoglobulin GInducible T-Cell Co-Stimulator Proteininterleukin-7 receptor, alpha chainPneumococcal VaccinesPolysaccharides, BacterialReceptors, Interleukin-7HIV infectionIgG2 antibodiesIL-7 receptorpneumococcal 23-polyvalent vaccineT follicular cells

Identifiers

PMID31068934
PMCPMC6491457
OpenAlexW2929539908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.