Evidence map›Paper›PMID 31068927›Full record

ArticleFrontiers in immunology2019

Impaired STAT3-Dependent Upregulation of IL2Rα in B Cells of a Patient With a STAT1 Gain-of-Function Mutation.

Menno C van Zelm, Julian J Bosco, Pei M Aui, Samuel De Jong, Fiona Hore-Lacy, Robyn E O'Hehir, Robert G Stirling, Paul U Cameron

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Menno C van ZelmDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Julian J BoscoAllergy, Asthma and Clinical Immunology Service, Department of Respiratory, Allergy and Clinical Immunology (Research), Central Clinical School, Monash University, The Alfred Hospital, Melbourne, VIC, Australia.
Pei M AuiDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Samuel De JongDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Fiona Hore-LacyAllergy, Asthma and Clinical Immunology Service, Department of Respiratory, Allergy and Clinical Immunology (Research), Central Clinical School, Monash University, The Alfred Hospital, Melbourne, VIC, Australia.
Robyn E O'HehirAllergy, Asthma and Clinical Immunology Service, Department of Respiratory, Allergy and Clinical Immunology (Research), Central Clinical School, Monash University, The Alfred Hospital, Melbourne, VIC, Australia.
Robert G StirlingAllergy, Asthma and Clinical Immunology Service, Department of Respiratory, Allergy and Clinical Immunology (Research), Central Clinical School, Monash University, The Alfred Hospital, Melbourne, VIC, Australia.
Paul U CameronThe Jeffrey Modell Diagnostic and Research Centre for Primary Immunodeficiencies in Melbourne, Melbourne, VIC, Australia.
Monash University · AUJeffrey Modell Foundation · AUThe Alfred Hospital · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterozygous

Indexed as

Gain of Function MutationB-LymphocytesGene RearrangementGenotypeHumansImmunoglobulinsImmunophenotypingInterleukin-2 Receptor alpha SubunitLymphocyte ActivationMalePhosphorylationSignal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorImmunoglobulinsInterleukin-2 Receptor alpha SubunitSTAT1 protein, humanSTAT1 Transcription FactorSTAT3 protein, humanSTAT3 Transcription Factorchronic mucocutaneous candidiasisgain-of-functionhypogammaglobulinemiaIL2RαSTAT1STAT3

Identifiers

PMID31068927
PMCPMC6491679
OpenAlexW2941676523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.