ReviewFrontiers in neuroscience2019
The Interplay Between Stress, Inflammation, and Emotional Attention: Relevance for Depression.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 94 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Mindfulness-Based Intervention on Psychophysical Health in Patients Undergoing Hemodialysis: An Experimental Study
Effects of Mindfulness Meditation on Quality of Sleep, Perceived Stress, Serum Cortisol, and C-reactive Protein in Hemodialysis Patients
Who cites it
94 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Anti-inflammatory diets and mental health: a scoping review of randomized controlled trials and systematic evidence syntheses.Frontiers in nutrition · 2026Pooled it
- Guideline
- Vitamin E, Alpha-Tocopherol, and Its Effects on Depression and Anxiety: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Transcranial magnetic stimulation (TMS) for geriatric depression.Ageing research reviews · 2022Pooled it
- Effect of attention bias modification on depressive affect.Scientific reports · 2025Trial
- Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment: A Prespecified Analysis of the IMPACT BCN Randomized Clinical Trial.JAMA network open · 2023Trial
- Inflammatory Factors Associated with Late-Life Depressive Symptoms in Oldest-Old Patients with Type 2 Diabetes.International journal of molecular sciences · 2026Article
- Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa.Brain, behavior, & immunity - health · 2026Article
- Diagnosis of depression in adolescence signals improved inflammatory health in adulthood: Results from a nationally representative longitudinal study.Brain, behavior, and immunity · 2026Article
- Energy Allocation Resilience and Endocrine Integration.International journal of molecular sciences · 2026Review
- rTMS for treatment resistant depression - a single center community experience.Frontiers in psychiatry · 2026Article
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Modulation of IL-1β and TGF-β1 Gene Expression in Stress-Induced Depression Rat Supplemented with Malaysian Acacia Honey.Foods (Basel, Switzerland) · 2025Article
- Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder.International journal of molecular sciences · 2025Article
- Functional status modifies the impact of tumor necrosis factor-alpha on depression treatment response.BJPsych open · 2025Article
- Association between the psychological frailty index and stroke: a cohort study from CHARLS.Scientific reports · 2025Article
- Ambient fine particulate matter and mortality risk among people with disability in Korea based on the National Health Insurance database: a retrospective cohort study.BMC public health · 2025Article
- Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice.Scientific reports · 2025Article
- The Relationships Between Subjective Well-Being and Frailty: Staying With a Positive Mind, Stepping Away From Accelerated Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Context is Complex: Challenges and opportunities addressing contextual factors in manual therapy mechanisms research.International journal of osteopathic medicine : IJOM · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is among the most significant public mental health issues. A growing body of research implicates inflammation in the etiology and pathophysiology of depression. Yet, the results are somewhat inconsistent, leading to burgeoning attempts to identify associations between components of innate immune system involved in inflammation and specific symptoms of depression, including attention to emotional information. Negative attentional bias, defined as a tendency to direct attention toward negatively valenced information, is one of the core cognitive features of depression and is reliably demonstrated in depressed and vulnerable individuals. Altered attentional processing of emotional information and immunological changes are often precipitated by stressful events. Psychological stress triggers inflammatory activity and affective-cognitive changes that play a critical role in the onset, maintenance, and recurrence of depression. Using various designs, recent studies have reported a positive relationship between markers of inflammation and negative attentional bias on behavioral and neural levels, suggesting that the association between inflammation and emotional attention might represent a neurobiological pathway linking stress and depression. This mini-review summarizes current research on the reciprocal relationships between different types of stressors, emotional attention, inflammation, and depression, and discusses potential neurobiological mechanisms underlying these interactions. The integration provided aims to contribute toward understanding how biological and psychological processes interact to influence depression outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.