Evidence map›Paper›PMID 31068768›Full record

ArticleFrontiers in neuroscience2019

Isolated Murine Brain Model for Large-Scale Optoacoustic Calcium Imaging.

Sven Gottschalk, Oleksiy Degtyaruk, Benedict Mc Larney, Johannes Rebling, Xosé Luis Deán-Ben, Shy Shoham, Daniel Razansky

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Sven GottschalkInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Oleksiy DegtyarukInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Benedict Mc LarneyInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Johannes ReblingInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Xosé Luis Deán-BenInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Shy ShohamTech4Health and Neuroscience Institutes and Department of Ophthalmology, New York University Langone Health, New York, NY, United States.
Daniel RazanskyInstitute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany.
Helmholtz Zentrum München · DEUniversity of Zurich · CHInstitute for Biomedical Engineering · CHNYU Langone Health · USTechnical University of Munich · DE

Funding

Bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animalsUF1NS107680 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAZANSKY, DANIEL, RINBERG, DMITRY · 2018 to 2020
$3.4M
Five-dimensional optoacoustic tomography for large-scale electrophysiology in scattering brainsR21EY026382 · NEI · TECHNICAL UNIVERSITY OF MUNICH · PI RAZANSKY, DANIEL · 2015 to 2016
$317k
NEI NIH HHS R21 EY026382NINDS NIH HHS UF1 NS107680
6 · The paper itself

Abstract

Real-time visualization of large-scale neural dynamics in whole mammalian brains is hindered with existing neuroimaging methods having limited capacity when it comes to imaging large tissue volumes at high speeds. Optoacoustic imaging has been shown to be capable of real-time three-dimensional imaging of multiple cerebral hemodynamic parameters in rodents. However, optoacoustic imaging of calcium activity deep within the mammalian brain is hampered by strong blood absorption in the visible light spectrum as well as a lack of activity labels excitable in the near-infrared window. We have developed and validated an isolated whole mouse brain preparation labeled with genetically encoded calcium indicator GCaMP6f, which can closely resemble

Indexed as

calcium dynamicsfunctional neuroimagingGCaMP6fisolated brainoptoacoustic neuroimaging

Identifiers

PMID31068768
PMCPMC6491858
OpenAlexW2940698529

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.