Evidence map›Paper›PMID 31068622›Full record

ArticleScientific reports2019

VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.

Prestina Smith, Nathan Godde, Stefany Rubio, Melawit Tekeste, Eszter K Vladar, Jeffrey D Axelrod, Deborah J Henderson, Michal Milgrom-Hoffman, Patrick O Humbert, Lindsay Hinck

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Embryonic Mammary Gland Morphogenesis.Advances in experimental medicine and biology · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Generation of Mosaic Mammary Organoids by Differential Trypsinization.Journal of visualized experiments : JoVE · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Prestina SmithDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, 95064, USA.
Nathan GoddeCell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, VIC, 3002, Australia.
Stefany RubioDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, 95064, USA.
Melawit TekesteDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, 95064, USA.
Eszter K VladarDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4160-8894
Jeffrey D AxelrodDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-6094-7392
Deborah J HendersonCardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Michal Milgrom-HoffmanDepartment of Biochemistry & Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.
Patrick O HumbertCell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrews Place, Melbourne, VIC, 3002, Australia.ORCID http://orcid.org/0000-0002-1366-6691
Lindsay HinckDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, 95064, USA. lhinck@ucsc.edu.
University of California, Santa Cruz · USAustralian Centre for Disease Preparedness · AULa Trobe University · AUNewcastle University · GBStanford University · USThe University of Melbourne · AUUniversity of Colorado Denver · US

Funding

UNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2M
Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
UCSC Research Mentoring Internship Program: An Initiative to Increase Diversity and Inclusion in Genomics ResearchR25HG006836 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, RAMON, MARINA L · 2013 to 2025
$3.7M
PCP in vertebrate epithelial tubesR01GM098582 · NIGMS · STANFORD UNIVERSITY · PI AXELROD, JEFFREY D. · 2011 to 2019
$3.4M
RE: Regulation of mammary branching morphogenesis by Slit/Robo 1 signalingR01GM098897 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HINCK, LINDSAY E · 2011 to 2014
$1.6M
British Heart Foundation PG/11/76/29108NHGRI NIH HHS R25 HG006836NIGMS NIH HHS R01 GM098582NIGMS NIH HHS R01 GM098897NIGMS NIH HHS R25 GM058903NIGMS NIH HHS T32 GM008646
6 · The paper itself

Abstract

The VANGL family of planar cell polarity proteins is implicated in breast cancer however its function in mammary gland biology is unknown. Here, we utilized a panel of Vang1 and Vangl2 mouse alleles to examine the requirement of VANGL family members in the murine mammary gland. We show that Vang1CKO

Indexed as

AllelesAnimalsBody PatterningCell PolarityEmbryonic DevelopmentEpithelial CellsFemaleGene Knockdown TechniquesLoss of Function MutationMammary Glands, AnimalMembrane ProteinsMiceMice, TransgenicMutation, MissenseNerve Tissue ProteinsOrganogenesisLtap protein, mouseMembrane ProteinsNerve Tissue ProteinsRNA, MessengerVangl1 protein, mouse

Identifiers

PMID31068622
PMCPMC6506599
OpenAlexW2944148211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.