ArticleScientific reports2019
Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Engineering biomimetic zonal properties in fibre-reinforced hydrogels for functional cartilage tissue engineeringMaterials today. Bio · 2025Article
- Dual-Contrast Agent with Nanoparticle and Molecular Components in Photon-Counting Computed Tomography: Assessing Articular Cartilage Health.Annals of biomedical engineering · 2025Article
- Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage.Scientific reports · 2024Article
- Revealing Detailed Cartilage Function Through Nanoparticle Diffusion Imaging: A Computed Tomography & Finite Element Study.Annals of biomedical engineering · 2024Article
- Novel micro-MRI approach for subchondral trabecular bone analysis in patients with hip osteoarthritis is comparable to micro-CT approach.Croatian medical journal · 2022Article
- A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties.Diagnostics (Basel, Switzerland) · 2022Article
- Contrast solution properties and scan parameters influence the apparent diffusivity of computed tomography contrast agents in articular cartilage.Journal of the Royal Society, Interface · 2022Article
- Computational method for the optimization of quasimonoenergetic laser Compton x-ray sources for imaging applications.Applied optics · 2022Article
- Effects of human articular cartilage constituents on simultaneous diffusion of cationic and nonionic contrast agents.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health.Scientific reports · 2021Article
- Medical imaging of tissue engineering and regenerative medicine constructs.Biomaterials science · 2021Review
- dGEMRIC and CECT Comparison of Cationic and Anionic Contrast Agents in Cadaveric Human Metacarpal Cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation.Annals of biomedical engineering · 2020Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis of acute cartilage injuries enables monitoring of disease progression and improved treatment option planning to prevent post-traumatic osteoarthritis. In contrast-enhanced computed tomography (CECT), the changes in cationic agent diffusion within the tissue reflect cartilage degeneration. The diffusion in degenerated cartilage depends on proteoglycan (PG) content and water content, but each having an opposite effect on diffusion, thus compromising the diagnostic sensitivity. To overcome this limitation, we propose the simultaneous imaging of cationic (sensitive to PG and water contents) and non-ionic (sensitive to water content) agents. In this study, quantitative dual-energy CT (QDECT) imaging of two agents is reported for the first time at clinically feasible imaging time points. Furthermore, this is the first time synchrotron microCT with monochromatic X-rays is employed in cartilage CECT. Imaging was conducted at 1 and 2 h post contrast agent immersion. Intact, PG-depleted, and mechanically injured + PG-depleted cartilage samples (n = 33) were imaged in a mixture of cationic (iodine-based CA4+) and non-ionic (gadolinium-based gadoteridol) agents. Concurrent evaluation of CA4+ and gadoteridol partitions in cartilage is accomplished using QDECT. Subsequent normalization of the CA4+ partition with that of the gadoteridol affords CA4+ attenuations that significantly correlate with PG content - a key marker of OA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.