ArticleScientific reports2019
Platelet function in HIV plus dengue coinfection associates with reduced inflammation and milder dengue illness.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Dengue among immunocompromised patients: a systematic review and meta-analysis.Journal of travel medicine · 2025Pooled it
- Dengue-specific T-cell memory following natural infection: a comparative analysis between people living with HIV and HIV-negative individuals.Microbiology spectrum · 2026Observational
- Concurrent cryptococcal and dengue meningoencephalitis as initial presentation of human immunodeficiency virus infection in a patient from arbovirus-endemic northeastern Brazil: a case report.BMC infectious diseases · 2026Article
- Dengue and severe dengue.Clinical microbiology reviews · 2025Review
- Pathogenesis and seroprevalence of dengue virus in HIV-endemic regions: A global perspective.New microbes and new infections · 2025Article
- Dengue severity in rheumatoid arthritis patients under treatment with disease-modifying antirheumatic drugs.International journal of rheumatic diseases · 2024Article
- Dissecting Platelet's Role in Viral Infection: A Double-Edged Effector of the Immune System.International journal of molecular sciences · 2023Review
- Platelet caspase-1 and Bruton tyrosine kinase activation in patients with COVID-19 is associated with disease severity and reversed in vitro by ibrutinib.Research and practice in thrombosis and haemostasis · 2022Article
- Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R.Frontiers in immunology · 2022Article
- Thrombocytopenia in Virus Infections.Journal of clinical medicine · 2021Review
- Article
- Apoptosis characterization in mononuclear blood leukocytes of HIV patients during dengue acute disease.Scientific reports · 2020Article
- Infection prevention in the immunocompromised traveler due to conditions other than transplantation: a review.Therapeutic advances in infectious diseaseReview
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplification and clinical presentation in dengue. Platelets have been shown to participate in immune response in dengue and HIV. We hypothesized that altered platelet responses in HIV-infected subjects may contribute to altered inflammatory milieu and disease progression in dengue. We prospectively followed a cohort of 84 DENV-infected patients of whom 29 were coinfected with HIV under virological control. We report that dengue and HIV coinfection progress with reduced inflammation and milder disease progression with lower risk of vascular instability. Even though the degree of thrombocytopenia and platelet activation were similar between dengue-infected and HIV plus dengue-coinfected patients, plasma levels of the platelet-derived chemokines RANTES/CCL5 and PF4/CXCL4 were lower in coinfection. Consistently, platelets from coinfected patients presented defective secretion of the stored-chemokines PF4 and RANTES, but not newly synthesized IL-1β, when cultured ex vivo. These data indicate that platelets from HIV-infected subjects release lower levels of chemokines during dengue illness, which may contribute to milder clinical presentation during coinfection.
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