ArticleNeurology2019
Elevated cerebrospinal fluid total tau in former professional athletes with multiple concussions.
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Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Procoagulant Extracellular Vesicles Increase Neuronal Tau expression, Metabolism and Processing Through Tissue Factor and Protease Activated Receptor 2.Cellular and molecular neurobiology · 2026Article
- Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study.International journal of molecular sciences · 2024Article
- Tau: a biomarker of Huntington's disease.Molecular psychiatry · 2023Review
- Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts.Brain communications · 2023Article
- Vitreous Humor Biomarkers Reflect Pathological Changes in the Brain for Alzheimer's Disease and Chronic Traumatic Encephalopathy.Journal of Alzheimer's disease : JAD · 2023Article
- Blood-based Aβ42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new avenues for prevention.Acta neuropathologica · 2022Article
- Association of Plasma Biomarker Levels With Their CSF Concentration and the Number and Severity of Concussions in Professional Athletes.Neurology · 2022Article
- Tau as a Biomarker of Neurodegeneration.International journal of molecular sciences · 2022Review
- Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players.Journal of magnetic resonance imaging : JMRI · 2021Article
- Effects of head trauma and sport participation in young-onset Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 2 countries.
Foad TaghdiriFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.ORCID 0000-0002-3280-2804
Namita MultaniFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Apameh TaraziFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Seyed Ali NaeimiFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Mozghan KhodadadiFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Carrie EsopenkoFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Robin GreenFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Brenda ColellaFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Richard WennbergFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
David MikulisFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.ORCID 0000-0003-3956-0892
Karen Deborah DavisFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Ruma GoswamiFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Charles TatorFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.
Brian LevineFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada.ORCID 0000-0003-4343-811X
Maria Carmela TartagliaFrom the Tanz Centre for Research in Neurodegenerative Diseases (F.T., N.M., M.C.T.), Department of Rehabilitation Sciences (R. Green, B.C.), Institute of Medical Science (R. Green, R.W., D.M., K.D.D., C.T., B.L., M.C.T.), Department of Surgery (K.D.D.), and Department of Psychology and Neurology (B.L.), University of Toronto; Canadian Concussion Center (F.T., A.T., S.A.N., M.K., R. Green, B.C., R.W., D.M., K.D.D., R. Goswami, C.T., M.C.T.) and Division of Neurosurgery (C.T.), Toronto Western Hospital, Krembil Neuroscience Centre, University Health Network; Division of Neurology (A.T., S.A.N., R.W., M.C.T.) and Division of Neuroradiology (D.M.), Joint Department of Medical Imaging, University Health Network; and Rotman Research Institute at Baycrest (C.E.), Toronto, Ontario, Canada. carmela.tartaglia@uhn.ca.ORCID 0000-0002-5944-8497
University Health Network · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify CSF biomarkers that are related to decreased white matter (WM) integrity and poor cognitive performance in former professional athletes with a history of multiple concussions.
methodsConcentrations of phosphorylated tau181, total tau (t-tau), and β-amyloid in the CSF were measured in 3 groups: 22 former professional athletes with multiple concussions (mean ± SD age 55.9 ± 12.2 years), 5 healthy controls (age 57.4 ± 5.2 years), and 12 participants (age 60.0 ± 6.6 years) diagnosed with Alzheimer disease (AD). All participants in the former athletes group underwent diffusion tensor imaging to determine WM tract integrity and completed neuropsychological testing. We divided the former athletes group into those with normal (<300 pg/mL) and high (>300 pg/mL) CSF t-tau.
resultsCSF t-tau in the former athletes group was significantly higher than in the healthy control group (349.3 ± 182.6 vs 188.8 ± 39.9 pg/mL,
conclusionOur findings indicate that former athletes with multiple concussions are at increased risk of elevated levels of CSF t-tau and that high CSF t-tau is associated with reduced WM integrity and worse scores on the TMT Part B.
Indexed as
AthletesCognitionAdultAgedAlzheimer DiseaseAmyloid beta-PeptidesBrain ConcussionCase-Control StudiesChronic Traumatic EncephalopathyDiffusion Tensor ImagingFootballHockeyHumansMaleMiddle AgedNeuropsychological TestsAmyloid beta-Peptidesamyloid beta-protein (1-42)MAPT protein, humanPeptide Fragmentstau Proteins
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