Evidence map›Paper›PMID 31068470›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Multiple

Ashish Kapoor, Dongwon Lee, Luke Zhu, Elsayed Z Soliman, Megan L Grove, Eric Boerwinkle, Dan E Arking, Aravinda Chakravarti

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Identification and Functional Assessment of Candidate CausalCirculation. Genomic and precision medicine · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. A multi-enhancerGenome research · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Profile of Aravinda Chakravarti.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Ashish KapoorInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030; ashish.kapoor@uth.tmc.edu aravinda.chakravarti@nyulangone.org.
Dongwon LeeCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016.
Luke ZhuCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016.
Elsayed Z SolimanEpidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101.
Megan L GroveDivision of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030.
Eric BoerwinkleDivision of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Aravinda ChakravartiCenter for Human Genetics and Genomics, New York University School of Medicine, New York, NY 10016; ashish.kapoor@uth.tmc.edu aravinda.chakravarti@nyulangone.org.
The University of Texas Health Science Center at Houston · USCenter for Human Genetics · USJohns Hopkins University · USNew York University · USWake Forest University · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7M
GWAS TO GENE FUNCTION: NOS1AP AND OTHER QT INTERVAL GENESR01GM104469 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2014 to 2017
$2.5M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NIGMS NIH HHS R01 GM104469
6 · The paper itself

Abstract

The rationale for genome-wide association study (GWAS) results is sequence variation in

Indexed as

AllelesAnimalsCell LineElectrocardiographyGene Expression RegulationGenetic VariationGenome-Wide Association StudyHeartHumansMiceMyocardiumNAV1.5 Voltage-Gated Sodium ChannelQuantitative Trait LociRegulatory Sequences, Nucleic AcidNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humancis-regulatory variantsenhancersGWASQT intervalSCN5A

Identifiers

PMID31068470
PMCPMC6561183
OpenAlexW2944247923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.