Evidence map›Paper›PMID 31068434›Full record

ArticlemSphere2019

Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance.

Rachel L Darnell, Melanie K Knottenbelt, Francesca O Todd Rose, Ian R Monk, Timothy P Stinear, Gregory M Cook

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Synergistic potential of LeuBMC microbiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Antimicrobial Resistance and Its Spread Is a Global Threat.Antibiotics (Basel, Switzerland) · 2022
    Review
  13. Antimicrobial Effects ofMicroorganisms · 2022
    Article
  14. IreK-Mediated, Cell Wall-Protective Phosphorylation inJournal of proteome research · 2021
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rachel L DarnellDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Melanie K KnottenbeltDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Francesca O Todd RoseDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Ian R MonkDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Timothy P StinearDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.ORCID 0000-0003-0150-123X
Gregory M CookDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand greg.cook@otago.ac.nz.
The University of Melbourne · AUUniversity of Auckland · NZUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teixobactin is a new antimicrobial of significant interest. It is active against a number of multidrug-resistant pathogens, including

Indexed as

Gene Expression Regulation, BacterialAnti-Bacterial AgentsBacterial ProteinsDepsipeptidesDrug Resistance, BacterialEnterococcus faecalisGene DeletionGene Expression ProfilingGene Expression RegulationGenome, BacterialMicrobial Sensitivity TestsStaphylococcus aureusTranscription, GeneticAnti-Bacterial AgentsBacterial ProteinsDepsipeptidesteixobactinantimicrobial resistanceantimicrobial toleranceCroRSEnterococcusmechanisms of resistanceRNA sequencingteixobactin

Identifiers

PMID31068434
PMCPMC6506618
OpenAlexW2944300825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.